論文 - 詳細
| RRC ID | 43050 |
|---|---|
| 著者 | Shimadoi S, Takami A, Kondo Y, Okumura H, Nakao S. |
| タイトル | Macrophage colony-stimulating factor enhances rituximab-dependent cellular cytotoxicity by monocytes. |
| ジャーナル | Cancer Sci |
| Abstract |
Recent studies suggest that monocytes are the dominant effectors by which rituximab induces cell death in B-cell lymphoma. Because macrophage colony-stimulating factor (M-CSF) can enhance the cytotoxicity of monocytes, the authors examined whether this growth factor can enhance their ability to kill lymphoma cells in vitro. Monocytes derived from a healthy volunteer were cultured for 48 h in the presence or absence of M-CSF. Monocytes stimul ated with M-CSF were significantly more cytotoxic to Daudi B-cell lymphomas than unstimulated monocytes. Flow cytometry revealed that M-CSF increased monocyte expression of Fcgamma receptors III and I by 1.6- and 1.5-fold, whereas the expression of Fcgamma receptor II remained unchanged. These results suggest that pretreatment with M-CSF can improve the therapeutic efficacy of rituximab against intractable CD20(+) lymphoma. |
| 巻・号 | 98(9) |
| ページ | 1368-72 |
| 公開日 | 2007-9-1 |
| DOI | 10.1111/j.1349-7006.2007.00544.x |
| PII | CAS544 |
| PMID | 17640305 |
| MeSH | Adjuvants, Immunologic / physiology* Antibodies, Blocking / biosynthesis Antibodies, Blocking / pharmacology Antibodies, Monoclonal / physiology* Antibodies, Monoclonal / therapeutic use Antibodies, Monoclonal, Murine-Derived Antibody-Dependent Cell Cytotoxicity / immunology* Cell Line, Tumor Cells, Cultured Humans Lymphoma / immunology Lymphoma / metabolism Lymphoma / pathology Lymphoma / therapy Macrophage Colony-Stimulating Factor / physiology* Monocytes / immunology* Monocytes / metabolism Receptors, IgG / biosynthesis Receptors, IgG / immunology Rituximab |
| IF | 4.966 |
| 引用数 | 5 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MOLT-4(RCB0206) Daudi THP-1(RCB1189) |