Reference - Detail
| RRC ID | 4305 |
|---|---|
| Author | Taubert S, Hansen M, Van Gilst MR, Cooper SB, Yamamoto KR. |
| Title | The Mediator subunit MDT-15 confers metabolic adaptation to ingested material. |
| Journal | PLoS Genet |
| Abstract |
In eukaryotes, RNA polymerase II (Pol(II)) dependent gene expression requires accessory factors termed transcriptional coregulators. One coregulator that universally contributes to Pol(II)-dependent transcription is the Mediator, a multisubunit complex that is targeted by many transcriptional regulatory factors. For example, the Caenorhabditis elegans Mediator subunit MDT-15 confers the regulatory actions of the sterol response element binding protein SBP-1 and the nuclear hormone receptor NHR-49 on fatty acid metabolism. Here, we demonstrate that MDT-15 displays a broader spectrum of activities, and that it integrates metabolic responses to materials ingested by C. elegans. Depletion of MDT-15 protein or mutation of the mdt-15 gene abrogated induction of specific detoxification genes in response to certain xenobiotics or heavy metals, rendering these animals hypersensitive to toxin exposure. Intriguingly, MDT-15 appeared to selectively affect stress responses related to ingestion, as MDT-15 functional defects did not abrogate other stress responses, e.g., thermotolerance. Together with our previous finding that MDT-15:NHR-49 regulatory complexes coordinate a sector of the fasting response, we propose a model whereby MDT-15 integrates several transcriptional regulatory pathways to monitor both the availability and quality of ingested materials, including nutrients and xenobiotic compounds. |
| Volume | 4(2) |
| Pages | e1000021 |
| Published | 2008-2-29 |
| DOI | 10.1371/journal.pgen.1000021 |
| PMID | 18454197 |
| PMC | PMC2265483 |
| MeSH | Adaptation, Physiological Animals Caenorhabditis elegans / drug effects Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / antagonists & inhibitors Caenorhabditis elegans Proteins / chemistry Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Food Gene Expression Profiling Genes, Helminth Heat-Shock Response / genetics Heat-Shock Response / physiology Inactivation, Metabolic Lipid Metabolism Metals, Heavy / metabolism Metals, Heavy / toxicity Models, Biological Mutation Protein Subunits RNA Interference Trans-Activators / antagonists & inhibitors Trans-Activators / chemistry Trans-Activators / genetics Trans-Activators / metabolism* Xenobiotics / metabolism Xenobiotics / toxicity |
| IF | 5.175 |
| Times Cited | 66 |
| WOS Category | GENETICS & HEREDITY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Wikipedia |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm2182 |