RRC ID 43071
Author Nagayama K, Kohno T, Sato M, Arai Y, Minna JD, Yokota J.
Title Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution.
Journal Genes Chromosomes Cancer
Abstract Whole genome scanning of 43 lung cancer cell lines at a 100-kb resolution led to identification of 51 genomic regions with homozygous deletions (HDs). The regions contained 113 genes, including two known tumor suppressor genes, RBl (RB) and CDKN2A (p16), and eight genes previously reported as being candidate tumor suppressor genes, such as PTPRD and LRP1B. Three miRNA genes, MIRNLET7C (let-7c), MIRN99A (hsa-mir-99a), and MIRN125B2 (hsa-mir-125b-2), were also mapped in a region with HD at 21q11-q21. The present study provides a list of protein- and miRNA-encoding genes whose inactivation is possibly involved in lung carcinogenesis.
Volume 46(11)
Pages 1000-10
Published 2007-11-1
DOI 10.1002/gcc.20485
PMID 17674361
MeSH Carcinoma, Non-Small-Cell Lung / genetics Carcinoma, Small Cell / genetics Cell Line, Tumor Gene Deletion* Genome* Homozygote* Humans Lung Neoplasms / genetics*
IF 3.444
Times Cited 55
Human and Animal Cells