論文 - 詳細
| RRC ID | 43071 |
|---|---|
| 著者 | Nagayama K, Kohno T, Sato M, Arai Y, Minna JD, Yokota J. |
| タイトル | Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution. |
| ジャーナル | Genes Chromosomes Cancer |
| Abstract |
Whole genome scanning of 43 lung cancer cell lines at a 100-kb resolution led to identification of 51 genomic regions with homozygous deletions (HDs). The regions contained 113 genes, including two known tumor suppressor genes, RBl (RB) and CDKN2A (p16), and eight genes previously reported as being candidate tumor suppressor genes, such as PTPRD and LRP1B. Three miRNA genes, MIRNLET7C (let-7c), MIRN99A (hsa-mir-99a), and MIRN125B2 (hsa-mir-125b-2), were also mapped in a region with HD at 21q11-q21. The present study provides a list of protein- and miRNA-encoding genes whose inactivation is possibly involved in lung carcinogenesis. |
| 巻・号 | 46(11) |
| ページ | 1000-10 |
| 公開日 | 2007-11-1 |
| DOI | 10.1002/gcc.20485 |
| PMID | 17674361 |
| MeSH | Carcinoma, Non-Small-Cell Lung / genetics Carcinoma, Small Cell / genetics Cell Line, Tumor Gene Deletion* Genome* Homozygote* Humans Lung Neoplasms / genetics* |
| IF | 3.444 |
| 引用数 | 55 |
| WOS 分野 | GENETICS & HEREDITY ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | |