論文 - 詳細
| RRC ID | 43088 |
|---|---|
| 著者 | Ishiguro K, Ando T, Maeda O, Ohmiya N, Niwa Y, Kadomatsu K, Goto H. |
| タイトル | Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Ginger has been used throughout the world as spice, food and traditional herb. We found that 6-gingerol, a phenolic alkanone isolated from ginger, enhanced the TRAIL-induced viability reduction of gastric cancer cells while 6-gingerol alone affected viability only slightly. 6-Gingerol facilitated TRAIL-induced apoptosis by increasing TRAIL-induced caspase-3/7 activation. 6-Gingerol was shown to down-regulate the expression of cIAP1, which suppresses caspase-3/7 activity, by inhibiting TRAIL-induced NF-kappaB activation. As 6-shogaol has a chemical structure similar to 6-gingerol, we also assessed the effect of 6-shogaol on the viability of gastric cancer cells. Unlike 6-gingerol, 6-shogaol alone reduced the viability of gastric cancer cells. 6-Shogaol was shown to damage microtubules and induce mitotic arrest. These findings indicate for the first time that in gastric cancer cells, 6-gingerol enhances TRAIL-induced viability reduction by inhibiting TRAIL-induced NF-kappaB activation while 6-shogaol alone reduces viability by damaging microtubules. |
| 巻・号 | 362(1) |
| ページ | 218-223 |
| 公開日 | 2007-10-12 |
| DOI | 10.1016/j.bbrc.2007.08.012 |
| PII | S0006-291X(07)01711-1 |
| PMID | 17706603 |
| MeSH | Animals Caspase 3 / metabolism Caspase 7 / metabolism Catechols / pharmacology* Cell Line, Tumor Cell Survival Fatty Alcohols / pharmacology* Humans Mice Mice, Nude Microtubules / metabolism NF-kappa B / metabolism Plant Extracts / pharmacology Stomach Neoplasms / metabolism* Stomach Neoplasms / pathology* TNF-Related Apoptosis-Inducing Ligand / metabolism Zingiber officinale / metabolism* |
| IF | 2.985 |
| 引用数 | 78 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HGC-27(RCB0500) |