| RRC ID |
43088
|
| 著者 |
Ishiguro K, Ando T, Maeda O, Ohmiya N, Niwa Y, Kadomatsu K, Goto H.
|
| タイトル |
Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms.
|
| ジャーナル |
Biochem Biophys Res Commun
|
| Abstract |
Ginger has been used throughout the world as spice, food and traditional herb. We found that 6-gingerol, a phenolic alkanone isolated from ginger, enhanced the TRAIL-induced viability reduction of gastric cancer cells while 6-gingerol alone affected viability only slightly. 6-Gingerol facilitated TRAIL-induced apoptosis by increasing TRAIL-induced caspase-3/7 activation. 6-Gingerol was shown to down-regulate the expression of cIAP1, which suppresses caspase-3/7 activity, by inhibiting TRAIL-induced NF-kappaB activation. As 6-shogaol has a chemical structure similar to 6-gingerol, we also assessed the effect of 6-shogaol on the viability of gastric cancer cells. Unlike 6-gingerol, 6-shogaol alone reduced the viability of gastric cancer cells. 6-Shogaol was shown to damage microtubules and induce mitotic arrest. These findings indicate for the first time that in gastric cancer cells, 6-gingerol enhances TRAIL-induced viability reduction by inhibiting TRAIL-induced NF-kappaB activation while 6-shogaol alone reduces viability by damaging microtubules.
|
| 巻・号 |
362(1)
|
| ページ |
218-223
|
| 公開日 |
2007-10-12
|
| DOI |
10.1016/j.bbrc.2007.08.012
|
| PII |
S0006-291X(07)01711-1
|
| PMID |
17706603
|
| MeSH |
Animals
Caspase 3 / metabolism
Caspase 7 / metabolism
Catechols / pharmacology*
Cell Line, Tumor
Cell Survival
Fatty Alcohols / pharmacology*
Ginger / metabolism*
Humans
Mice
Mice, Nude
Microtubules / metabolism
NF-kappa B / metabolism
Plant Extracts / pharmacology
Stomach Neoplasms / metabolism*
Stomach Neoplasms / pathology*
TNF-Related Apoptosis-Inducing Ligand / metabolism
|
| IF |
2.985
|
| 引用数 |
78
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
|
