論文 - 詳細
| RRC ID | 43133 |
|---|---|
| 著者 | Efdi M, Ohguchi K, Akao Y, Nozawa Y, Koketsu M, Ishihara H. |
| タイトル | N-trans-feruloyltyramine as a melanin biosynthesis inhibitor. |
| ジャーナル | Biol Pharm Bull |
| Abstract |
In this study, we examined the effect of N-trans-feruloyltyramine (FA) on melanogenesis in mouse B16 melanoma cells. Melanogenesis was inhibited by FA in a dose-dependent manner. FA exhibited a greater potency than kojic acid as a standard inhibitor of melanogenesis. Moreover, treatment of B16 melanoma cells with FA was found to cause marked decreases in the expression levels of tyrosinase. FA-induced downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells. |
| 巻・号 | 30(10) |
| ページ | 1972-4 |
| 公開日 | 2007-10-1 |
| DOI | 10.1248/bpb.30.1972 |
| PII | JST.JSTAGE/bpb/30.1972 |
| PMID | 17917275 |
| MeSH | Animals Annonaceae / chemistry* Blotting, Western Cell Line, Tumor Chromatography, High Pressure Liquid Coumaric Acids / isolation & purification Coumaric Acids / pharmacology* Magnetic Resonance Spectroscopy Mass Spectrometry Melanins / antagonists & inhibitors* Melanins / biosynthesis* Melanoma, Experimental / drug therapy Melanoma, Experimental / enzymology Melanoma, Experimental / pathology Mice Monophenol Monooxygenase / metabolism Plant Extracts / chemistry Signal Transduction / drug effects Spectrophotometry, Infrared Tyramine / analogs & derivatives* Tyramine / isolation & purification Tyramine / pharmacology |
| IF | 1.863 |
| 引用数 | 21 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | B16 melanoma(RCB1283) |