論文 - 詳細
| RRC ID | 43191 |
|---|---|
| 著者 | Liu X, Inomata M, Ogawara T, Saneyoshi M, Yamaguchi T. |
| タイトル | Telomere shortening in human HL60 cells by treatment with 3'-azido-2',3'-dideoxynucleosides and telomerase inhibition by their 5'-triphosphates. |
| ジャーナル | Nucleosides Nucleotides Nucleic Acids |
| Abstract |
Telomerase is thought to play an important role in the mechanism of tumor cell immortalization by maintenance of telomere length. To obtain information on the susceptibility of telomerase to nucleoside analogues, the effects of base-modified 3'-azido-2',3'-dideoxynucleoside triphosphates on the enzyme were investigated. It is suggested that the 2-amino group of the nucleotide purine nucleus is important for the inhibitory activity. Telomere shortening caused by long-term treatment with these nucleosides is also described. |
| 巻・号 | 26(8-9) |
| ページ | 1067-71 |
| 公開日 | 2007-1-1 |
| DOI | 10.1080/15257770701515468 |
| PII | 787865230 |
| PMID | 18058538 |
| MeSH | Dideoxyadenosine / analogs & derivatives Dideoxyadenosine / chemistry Dideoxyadenosine / pharmacology Dideoxynucleosides / chemistry Dideoxynucleosides / pharmacology* Dideoxynucleotides / chemistry Dideoxynucleotides / pharmacology* Drug Design Enzyme Inhibitors / chemistry Enzyme Inhibitors / pharmacology HL-60 Cells Humans Telomerase / antagonists & inhibitors* Telomere / drug effects* |
| IF | 1.556 |
| 引用数 | 6 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |