Reference - Detail
| RRC ID | 43203 |
|---|---|
| Author | Kanemura N, Tsurumi H, Okuno M, Matsushima-Nishiwaki R, Shimizu M, Moriwaki H. |
| Title | Retinoid X receptor alpha is highly phosphorylated in retinoic acid-resistant HL-60R cells and the combination of 9-cis retinoic acid plus MEK inhibitor induces apoptosis in the cells. |
| Journal | Leuk Res |
| Abstract |
We examined the effects of 9-cis retinoic acid (RA) on the expression levels of retinoid X receptor alpha (RXR alpha) and its phosphorylated form (p-RXR alpha) in HL-60 and HL-60R cells. 9-cis RA reduced both RXR alpha and p-RXR alpha in HL-60 cells, but did neither in HL-60R cells. However, when the HL-60R cells were treated with the combination of 9-cis RA plus PD98059, MEK inhibitor, the p-RXR alpha and RXR alpha proteins all markedly decreased. Moreover, the combination of those agents induced apoptosis in HL-60R cells. Phosphorylation of RXR alpha might be associated with RA-resistance in HL-60R cells. |
| Volume | 32(6) |
| Pages | 884-92 |
| Published | 2008-6-1 |
| DOI | 10.1016/j.leukres.2007.11.005 |
| PII | S0145-2126(07)00438-9 |
| PMID | 18082883 |
| MeSH | Alitretinoin Apoptosis / drug effects* Apoptosis / physiology Blotting, Western Butadienes / pharmacology Cell Proliferation / drug effects Drug Resistance, Neoplasm* Drug Therapy, Combination Enzyme Inhibitors / pharmacology Flavonoids / pharmacology HL-60 Cells Humans Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors* Mitogen-Activated Protein Kinase Kinases / metabolism Nitriles / pharmacology Phosphorylation / drug effects Retinoid X Receptor alpha / metabolism* Tretinoin / pharmacology* |
| IF | 2.214 |
| Times Cited | 13 |
| WOS Category | HEMATOLOGY ONCOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | HL60(RCB0041) |