| RRC ID |
43209
|
| Author |
Ouji Y, Yoshikawa M, Moriya K, Nishiofuku M, Matsuda R, Ishizaka S.
|
| Title |
Wnt-10b, uniquely among Wnts, promotes epithelial differentiation and shaft growth.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
Although Wnts are expressed in hair follicles throughout life from embryo to adult, and considered to be critical for their development and maturation, their roles remain largely unknown. In the present study, we investigated the effects of Wnts (Wnt-3a, Wnt-5a, Wnt-10b, and Wnt-11) on epithelial cell differentiation using adult mouse-derived primary skin epithelial cell (MPSEC) cultures and hair growth using hair follicle organ cultures. Only Wnt-10b showed evident promotion of epithelial cell differentiation and hair shaft growth, in contrast to Wnt-3a, 5a, and 11. Our results suggest that Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle.
|
| Volume |
367(2)
|
| Pages |
299-304
|
| Published |
2008-3-7
|
| DOI |
10.1016/j.bbrc.2007.12.091
|
| PII |
S0006-291X(07)02720-9
|
| PMID |
18155657
|
| MeSH |
Animals
Cell Differentiation / physiology
Cell Proliferation
Cells, Cultured
Epithelial Cells / cytology*
Epithelial Cells / metabolism*
Hair Follicle / cytology*
Hair Follicle / metabolism*
Mice
Mice, Inbred C3H
Wnt Proteins / metabolism*
|
| IF |
2.985
|
| Times Cited |
34
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
|
