論文 - 詳細
| RRC ID | 43209 |
|---|---|
| 著者 | Ouji Y, Yoshikawa M, Moriya K, Nishiofuku M, Matsuda R, Ishizaka S. |
| タイトル | Wnt-10b, uniquely among Wnts, promotes epithelial differentiation and shaft growth. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Although Wnts are expressed in hair follicles throughout life from embryo to adult, and considered to be critical for their development and maturation, their roles remain largely unknown. In the present study, we investigated the effects of Wnts (Wnt-3a, Wnt-5a, Wnt-10b, and Wnt-11) on epithelial cell differentiation using adult mouse-derived primary skin epithelial cell (MPSEC) cultures and hair growth using hair follicle organ cultures. Only Wnt-10b showed evident promotion of epithelial cell differentiation and hair shaft growth, in contrast to Wnt-3a, 5a, and 11. Our results suggest that Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. |
| 巻・号 | 367(2) |
| ページ | 299-304 |
| 公開日 | 2008-3-7 |
| DOI | 10.1016/j.bbrc.2007.12.091 |
| PII | S0006-291X(07)02720-9 |
| PMID | 18155657 |
| MeSH | Animals Cell Differentiation / physiology Cell Proliferation Cells, Cultured Epithelial Cells / cytology* Epithelial Cells / metabolism* Hair Follicle / cytology* Hair Follicle / metabolism* Mice Mice, Inbred C3H Wnt Proteins / metabolism* |
| IF | 2.985 |
| 引用数 | 34 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | |