論文 - 詳細
RRC ID | 4321 |
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著者 | You YJ, Kim J, Raizen DM, Avery L. |
タイトル | Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety. |
ジャーナル | Cell Metab |
Abstract |
Despite the prevalence of obesity and its related diseases, the signaling pathways for appetite control and satiety are not clearly understood. Here we report C. elegans quiescence behavior, a cessation of food intake and movement that is possibly a result of satiety. C. elegans quiescence shares several characteristics of satiety in mammals. It is induced by high-quality food, it requires nutritional signals from the intestine, and it depends on prior feeding history: fasting enhances quiescence after refeeding. During refeeding after fasting, quiescence is evoked, causing gradual inhibition of food intake and movement, mimicking the behavioral sequence of satiety in mammals. Based on these similarities, we propose that quiescence results from satiety. This hypothesized satiety-induced quiescence is regulated by peptide signals such as insulin and TGF-beta. The EGL-4 cGMP-dependent protein kinase functions downstream of insulin and TGF-beta in sensory neurons including ASI to control quiescence in response to food intake. |
巻・号 | 7(3) |
ページ | 249-57 |
公開日 | 2008-3-1 |
DOI | 10.1016/j.cmet.2008.01.005 |
PII | S1550-4131(08)00006-5 |
PMID | 18316030 |
PMC | PMC3786678 |
MeSH | Animal Nutritional Physiological Phenomena Animals Appetite Regulation Caenorhabditis elegans / enzymology Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cyclic GMP / metabolism* Cyclic GMP-Dependent Protein Kinases / metabolism Eating* Fasting / metabolism Insulin / metabolism* Ion Channels / metabolism Locomotion* Models, Animal Mutation Neurons / metabolism Receptor, Insulin / metabolism Satiety Response* Signal Transduction* Transforming Growth Factor beta / metabolism* |
IF | 21.567 |
引用数 | 147 |
WOS 分野 | ENDOCRINOLOGY & METABOLISM CELL BIOLOGY |
リソース情報 | |
線虫 | tm1325 tm903 |