RRC ID 4326
著者 Darland-Ransom M, Wang X, Sun CL, Mapes J, Gengyo-Ando K, Mitani S, Xue D.
タイトル Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry.
ジャーナル Science
Abstract The asymmetrical distribution of phospholipids on the plasma membrane is critical for maintaining cell integrity and physiology and for regulating intracellular signaling and important cellular events such as clearance of apoptotic cells. How phospholipid asymmetry is established and maintained is not fully understood. We report that the Caenorhabditis elegans P-type adenosine triphosphatase homolog, TAT-1, is critical for maintaining cell surface asymmetry of phosphatidylserine (PS). In animals deficient in tat-1, PS is abnormally exposed on the cell surface, and normally living cells are randomly lost through a mechanism dependent on PSR-1, a PS-recognizing phagocyte receptor, and CED-1, which contributes to recognition and engulfment of apoptotic cells. Thus, tat-1 appears to function in preventing appearance of PS in the outer leaflet of plasma membrane, and ectopic exposure of PS on the cell surface may result in removal of living cells by neighboring phagocytes.
巻・号 320(5875)
ページ 528-31
公開日 2008-4-25
DOI 10.1126/science.1155847
PII 320/5875/528
PMID 18436785
MeSH Animals Animals, Genetically Modified Apoptosis Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Membrane / metabolism* Germ Cells / cytology Germ Cells / metabolism Muscle Cells / cytology Muscle Cells / metabolism Neurons / cytology Neurons / metabolism Phagocytosis Phosphatidylserines / metabolism* Phospholipid Transfer Proteins / genetics Phospholipid Transfer Proteins / metabolism* RNA Interference Recombinant Fusion Proteins / metabolism
IF 41.846
引用数 96
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
線虫 tm1034 tm1275 tm469