RRC ID 43309
著者 Kimura Y, Sumiyoshi M, Baba K.
タイトル Anti-tumor actions of major component 3'-O-acetylhamaudol of Angelica japonica roots through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation.
ジャーナル Cancer Lett
Abstract We recently demonstrated that two chalcones isolated from Angelica keiskei roots have anti-tumor and anti-metastatic activities through the inhibition of tumor-induced angiogenesis, but the anti-tumor substances of Angelica japonica roots are unknown. We attempted to clarify the anti-tumor action and its mechanisms of a major component 3'-O-acetylhamaudol isolated from A. japonica roots. We first examined the effects of 3'-O-acetylhamaudol on tumor growth in colon 26-bearing mice. Furthermore, we examined the effects of 3'-O-acetylhamaudol on angiogenic factors (vascular endothelial growth factor receptor-2 (VEGFR-2) phosphorylation in human umbilical vein endothelial cells (HUVECs), and vascular endothelial growth factor (VEGF) production and hypoxia-inducible factor (HIF)-1alpha expression in tumors). 3'-O-Acetylhamaudol (25 and 50 mg/kg, twice daily) inhibited the tumor growth in colon 26-bearing mice. Although 3'-O-acetylhamudol had no effect on the VEGF production and HIF-1alpha in colon 26 cells, it (10 microM) inhibited the VEGF-induced angiogenesis and VEGF-induced VEGFR-2 phosphorylation in HUVECs. 3'-O-Acetylhamaudol has anti-tumor effects mediated through dual mechanisms, i.e., anti-angiogenic actions and the modulation of the immune system in the spleen and small intestine in tumor-bearing mice.
巻・号 265(1)
ページ 84-97
公開日 2008-6-28
DOI 10.1016/j.canlet.2008.02.009
PII S0304-3835(08)00088-8
PMID 18358599
MeSH Angelica / chemistry* Angiogenesis Inhibitors / pharmacology Angiogenesis Inhibitors / therapeutic use Animals Antineoplastic Agents, Phytogenic / pharmacology* Antineoplastic Agents, Phytogenic / therapeutic use Cells, Cultured Chromones / pharmacology* Chromones / therapeutic use Colonic Neoplasms / blood supply Colonic Neoplasms / drug therapy Colonic Neoplasms / pathology Endothelial Cells / drug effects Endothelial Cells / metabolism Endothelium, Vascular / cytology Extracellular Space / metabolism Humans Hypoxia-Inducible Factor 1, alpha Subunit / metabolism Intestinal Mucosa / immunology Intestinal Mucosa / pathology* Intestine, Small / immunology Intestine, Small / pathology Lymphocyte Activation / drug effects* Male Mice Mice, Inbred BALB C Neoplasm Transplantation Neovascularization, Pathologic / drug therapy* Phosphorylation Plant Roots / chemistry* Transplantation, Heterologous Vascular Endothelial Growth Factor Receptor-2 / metabolism
IF 7.36
引用数 15
WOS 分野 ONCOLOGY
リソース情報
ヒト・動物細胞 YAC-1(RCB1165)