論文 - 詳細
| RRC ID | 43310 |
|---|---|
| 著者 | Satoh T, Arii J, Suenaga T, Wang J, Kogure A, Uehori J, Arase N, Shiratori I, Tanaka S, Kawaguchi Y, Spear PG, Lanier LL, Arase H. |
| タイトル | PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B. |
| ジャーナル | Cell |
| Abstract |
Glycoprotein B (gB) is one of the essential components for infection by herpes simplex virus-1 (HSV-1). Although several cellular receptors that associate with glycoprotein D (gD), such as herpes virus entry mediator (HVEM) and Nectin-1, have been identified, specific molecules that mediate HSV-1 infection by associating with gB have not been elucidated. Here, we found that paired immunoglobulin-like type 2 receptor (PILR) alpha associates with gB, and cells transduced with PILRalpha become susceptible to HSV-1 infection. Furthermore, HSV-1 infection of human primary cells expressing both HVEM and PILRalpha was blocked by either anti-PILRalpha or anti-HVEM antibody. Our results demonstrate that cellular receptors for both gB and gD are required for HSV-1 infection and that PILRalpha plays an important role in HSV-1 infection as a coreceptor that associates with gB. These findings uncover a crucial aspect of the mechanism underlying HSV-1 infection. |
| 巻・号 | 132(6) |
| ページ | 935-44 |
| 公開日 | 2008-3-21 |
| DOI | 10.1016/j.cell.2008.01.043 |
| PII | S0092-8674(08)00205-5 |
| PMID | 18358807 |
| PMC | PMC2394663 |
| MeSH | Animals Antibodies, Monoclonal / metabolism CHO Cells Cell Line Cells, Cultured Cricetinae Cricetulus Herpes Simplex / metabolism* Herpes Simplex / virology Herpesvirus 1, Human / metabolism* Humans Membrane Glycoproteins / metabolism* Receptors, Immunologic / metabolism* Receptors, Virus / metabolism* Transfection Viral Envelope Proteins / metabolism* |
| IF | 38.637 |
| 引用数 | 180 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 30 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| ヒト・動物細胞 | 293T(RCB2202) COS-7(RCB0539) |