RRC ID |
43325
|
著者 |
Ohguchi K, Koike M, Suwa Y, Koshimizu S, Mizutani Y, Nozawa Y, Akao Y.
|
タイトル |
Inhibitory effects of whisky congeners on melanogenesis in mouse B16 melanoma cells.
|
ジャーナル |
Biosci Biotechnol Biochem
|
Abstract |
We examined the effect of whisky congeners, substances other than ethanol in whisky, on melanogenesis in mouse B16 melanoma cells. Treatment with whisky congeners significantly blocked melanogenesis. Our results indicate that the inhibitory effects of whisky congeners on melanogenesis is due to direct inhibition of tyrosinase activity and to suppression of tyrosinase protein levels.
|
巻・号 |
72(4)
|
ページ |
1107-10
|
公開日 |
2008-4-1
|
DOI |
10.1271/bbb.70734
|
PII |
JST.JSTAGE/bbb/70734
|
PMID |
18391453
|
MeSH |
Alcoholic Beverages* / analysis
Animals
Cattle
Cell Line, Tumor
Flavonoids / pharmacology*
Gene Expression Regulation, Neoplastic / drug effects
Melanins / biosynthesis*
Melanoma, Experimental / metabolism*
Mice
Monophenol Monooxygenase / metabolism
Phenols / pharmacology*
Polyphenols
alpha-MSH / pharmacology
|
IF |
1.516
|
引用数 |
8
|
WOS 分野
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
ヒト・動物細胞 |
|