論文 - 詳細
| RRC ID | 4339 |
|---|---|
| 著者 | Kawano T, Nagatomo R, Kimura Y, Gengyo-Ando K, Mitani S. |
| タイトル | Disruption of ins-11, a Caenorhabditis elegans insulin-like gene, and phenotypic analyses of the gene-disrupted animal. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
The insulin/insulin-like growth factor-I signaling (IIS) pathway regulates larval diapause, adult lifespan, fat metabolism, and stress-resistance in the nematode Caenorhabditis elegans. One of 38 C. elegans insulin-like genes, ins-11, was disrupted and phenotypic analyses of the gene-disrupted animal were performed. The gene-disruption exhibited a significant influence on the adult lifespan. It antagonized the lifespan extension induced by RNAi knockdown of another insulin-like gene, ins-7. Hence ins-11 appears to be necessary for lifespan extension caused by a decrease in the IIS pathway. This is the first description of gene-disruption of the C. elegans insulin-like gene that suppresses the lifespan extension. |
| 巻・号 | 70(12) |
| ページ | 3084-7 |
| 公開日 | 2006-12-1 |
| DOI | 10.1271/bbb.60472 |
| PII | JST.JSTAGE/bbb/60472 |
| PMID | 17151440 |
| MeSH | Animals Base Sequence Caenorhabditis elegans / genetics* DNA Primers DNA, Complementary Insulin / genetics* Phenotype RNA Interference |
| IF | 1.516 |
| 引用数 | 12 |
| WOS 分野 | CHEMISTRY, APPLIED FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 線虫 | tm1053 |