| RRC ID |
4339
|
| Author |
Kawano T, Nagatomo R, Kimura Y, Gengyo-Ando K, Mitani S.
|
| Title |
Disruption of ins-11, a Caenorhabditis elegans insulin-like gene, and phenotypic analyses of the gene-disrupted animal.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
The insulin/insulin-like growth factor-I signaling (IIS) pathway regulates larval diapause, adult lifespan, fat metabolism, and stress-resistance in the nematode Caenorhabditis elegans. One of 38 C. elegans insulin-like genes, ins-11, was disrupted and phenotypic analyses of the gene-disrupted animal were performed. The gene-disruption exhibited a significant influence on the adult lifespan. It antagonized the lifespan extension induced by RNAi knockdown of another insulin-like gene, ins-7. Hence ins-11 appears to be necessary for lifespan extension caused by a decrease in the IIS pathway. This is the first description of gene-disruption of the C. elegans insulin-like gene that suppresses the lifespan extension.
|
| Volume |
70(12)
|
| Pages |
3084-7
|
| Published |
2006-12-1
|
| DOI |
10.1271/bbb.60472
|
| PII |
JST.JSTAGE/bbb/60472
|
| PMID |
17151440
|
| MeSH |
Animals
Base Sequence
Caenorhabditis elegans / genetics*
DNA Primers
DNA, Complementary
Insulin / genetics*
Phenotype
RNA Interference
|
| IF |
1.516
|
| Times Cited |
12
|
|
WOS Category
|
CHEMISTRY, APPLIED
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| C.elegans |
tm1053 |
