RRC ID |
4339
|
著者 |
Kawano T, Nagatomo R, Kimura Y, Gengyo-Ando K, Mitani S.
|
タイトル |
Disruption of ins-11, a Caenorhabditis elegans insulin-like gene, and phenotypic analyses of the gene-disrupted animal.
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ジャーナル |
Biosci Biotechnol Biochem
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Abstract |
The insulin/insulin-like growth factor-I signaling (IIS) pathway regulates larval diapause, adult lifespan, fat metabolism, and stress-resistance in the nematode Caenorhabditis elegans. One of 38 C. elegans insulin-like genes, ins-11, was disrupted and phenotypic analyses of the gene-disrupted animal were performed. The gene-disruption exhibited a significant influence on the adult lifespan. It antagonized the lifespan extension induced by RNAi knockdown of another insulin-like gene, ins-7. Hence ins-11 appears to be necessary for lifespan extension caused by a decrease in the IIS pathway. This is the first description of gene-disruption of the C. elegans insulin-like gene that suppresses the lifespan extension.
|
巻・号 |
70(12)
|
ページ |
3084-7
|
公開日 |
2006-12-1
|
DOI |
10.1271/bbb.60472
|
PII |
JST.JSTAGE/bbb/60472
|
PMID |
17151440
|
MeSH |
Animals
Base Sequence
Caenorhabditis elegans / genetics*
DNA Primers
DNA, Complementary
Insulin / genetics*
Phenotype
RNA Interference
|
IF |
1.516
|
引用数 |
12
|
WOS 分野
|
CHEMISTRY, APPLIED
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
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リソース情報 |
線虫 |
tm1053 |