| RRC ID |
43420
|
| 著者 |
Kamon M, Fujita D, Goto N, Amano H, Sakamoto K.
|
| タイトル |
Prostaglandin F(2alpha) negatively regulates bone resorption in murine osteoclast development.
|
| ジャーナル |
Prostaglandins Other Lipid Mediat
|
| Abstract |
Prostaglandin (PG) E(2) promotes osteoclastic cell differentiation, but the physiological function of PGF(2alpha) remains unclear. We examined the physiological effects of PGF(2alpha) on osteoclast differentiation using a murine cell line, RAW264, and the column-purified murine bone marrow cells, both of which are differentiable into osteoclast-like multi-nuclear cells. Although PGF(2alpha) did not affect the number of differentiated osteoclasts, PGF(2alpha) reduced the bone resorption activity of osteoclasts developed from both cell types in a pit formation assay. Thus, PGF(2alpha) inhibits bone resorption without affecting the number of osteoclasts, providing a novel molecular mechanism underlying bone metabolism.
|
| 巻・号 |
87(1-4)
|
| ページ |
26-33
|
| 公開日 |
2008-12-1
|
| DOI |
10.1016/j.prostaglandins.2008.06.002
|
| PII |
S1098-8823(08)00054-3
|
| PMID |
18638564
|
| MeSH |
Animals
Bone Marrow Cells / drug effects
Bone Marrow Cells / metabolism
Bone Resorption / metabolism*
Cell Differentiation
Cell Line
Cell Nucleus / metabolism
Dinoprost / pharmacology*
Mice
Osteoclasts / cytology
Osteoclasts / drug effects*
Osteoclasts / metabolism*
Receptors, Prostaglandin / metabolism
Signal Transduction / drug effects
|
| IF |
2.283
|
| 引用数 |
5
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
RAW 264(RCB0535) |
