Reference - Detail
| RRC ID | 43422 |
|---|---|
| Author | Ishima T, Nishimura T, Iyo M, Hashimoto K. |
| Title | Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by donepezil: role of sigma-1 receptors and IP3 receptors. |
| Journal | Prog Neuropsychopharmacol Biol Psychiatry |
| Abstract |
In addition to acetylcholinesterase (AChE) inhibition, donepezil binds to sigma-1 receptors. In this study, we examined the effects of donepezil on nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. Donepezil significantly potentiated the NGF-induced neurite outgrowth in a concentration-dependent manner whereas the AChE inhibitor physostigmine did not alter NGF-induced neurite outgrowth. Potentiation of NGF-induced neurite outgrowth by donepezil was significantly blocked by co-administration of the selective sigma-1 receptor antagonist NE-100 or the inositol 1,4,5-triphosphate (IP3) receptor antagonist xestospongin C. These findings suggest that sigma-1 receptors and interaction with IP3 receptors may be involved in the pharmacological action of donepezil. |
| Volume | 32(7) |
| Pages | 1656-9 |
| Published | 2008-10-1 |
| DOI | 10.1016/j.pnpbp.2008.06.011 |
| PII | S0278-5846(08)00191-7 |
| PMID | 18647636 |
| MeSH | Analysis of Variance Animals Anisoles / pharmacology Cholinesterase Inhibitors / pharmacology* Donepezil Dose-Response Relationship, Drug Drug Synergism Indans / pharmacology* Inositol 1,4,5-Trisphosphate Receptors / antagonists & inhibitors Inositol 1,4,5-Trisphosphate Receptors / physiology* Macrocyclic Compounds / pharmacology Microtubule-Associated Proteins / metabolism Nerve Growth Factor / pharmacology* Neurites / drug effects* Oxazoles / pharmacology PC12 Cells / cytology PC12 Cells / drug effects Physostigmine / pharmacology Piperidines / pharmacology* Propylamines / pharmacology Rats Receptors, sigma / antagonists & inhibitors Receptors, sigma / physiology* |
| IF | 4.361 |
| Times Cited | 68 |
| WOS Category | CLINICAL NEUROLOGY PHARMACOLOGY & PHARMACY PSYCHIATRY NEUROSCIENCES |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | PC-12(RCB0009) |