| RRC ID |
43422
|
| Author |
Ishima T, Nishimura T, Iyo M, Hashimoto K.
|
| Title |
Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by donepezil: role of sigma-1 receptors and IP3 receptors.
|
| Journal |
Prog Neuropsychopharmacol Biol Psychiatry
|
| Abstract |
In addition to acetylcholinesterase (AChE) inhibition, donepezil binds to sigma-1 receptors. In this study, we examined the effects of donepezil on nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. Donepezil significantly potentiated the NGF-induced neurite outgrowth in a concentration-dependent manner whereas the AChE inhibitor physostigmine did not alter NGF-induced neurite outgrowth. Potentiation of NGF-induced neurite outgrowth by donepezil was significantly blocked by co-administration of the selective sigma-1 receptor antagonist NE-100 or the inositol 1,4,5-triphosphate (IP3) receptor antagonist xestospongin C. These findings suggest that sigma-1 receptors and interaction with IP3 receptors may be involved in the pharmacological action of donepezil.
|
| Volume |
32(7)
|
| Pages |
1656-9
|
| Published |
2008-10-1
|
| DOI |
10.1016/j.pnpbp.2008.06.011
|
| PII |
S0278-5846(08)00191-7
|
| PMID |
18647636
|
| MeSH |
Analysis of Variance
Animals
Anisoles / pharmacology
Cholinesterase Inhibitors / pharmacology*
Donepezil
Dose-Response Relationship, Drug
Drug Synergism
Indans / pharmacology*
Inositol 1,4,5-Trisphosphate Receptors / antagonists & inhibitors
Inositol 1,4,5-Trisphosphate Receptors / physiology*
Macrocyclic Compounds / pharmacology
Microtubule-Associated Proteins / metabolism
Nerve Growth Factor / pharmacology*
Neurites / drug effects*
Oxazoles / pharmacology
PC12 Cells / cytology
PC12 Cells / drug effects
Physostigmine / pharmacology
Piperidines / pharmacology*
Propylamines / pharmacology
Rats
Receptors, sigma / antagonists & inhibitors
Receptors, sigma / physiology*
|
| IF |
4.361
|
| Times Cited |
68
|
|
WOS Category
|
CLINICAL NEUROLOGY
PHARMACOLOGY & PHARMACY
PSYCHIATRY
NEUROSCIENCES
|
| Resource |
| Human and Animal Cells |
PC-12(RCB0009) |
