論文 - 詳細
| RRC ID | 435 |
|---|---|
| 著者 | Robert VJ, Sijen T, van Wolfswinkel J, Plasterk RH. |
| タイトル | Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences. |
| ジャーナル | Genes Dev |
| Abstract |
Protection of genomes against invasion by repetitive sequences, such as transposons, viruses, and repetitive transgenes, involves strong and selective silencing of these sequences. During silencing of repetitive transgenes, a trans effect ("cosuppression") occurs that results in silencing of cognate endogenous genes. Here we report RNA interference (RNAi) screens performed to catalog genes required for cosuppression in the Caenorhabditis elegans germline. We find factors with a putative role in chromatin remodeling and factors involved in RNAi. Together with molecular data also presented in this study, these results suggest that in C. elegans repetitive sequences trigger transcriptional gene silencing using RNAi and chromatin factors. |
| 巻・号 | 19(7) |
| ページ | 782-7 |
| 公開日 | 2005-4-1 |
| DOI | 10.1101/gad.332305 |
| PII | gad.332305 |
| PMID | 15774721 |
| PMC | PMC1074315 |
| MeSH | Animals Caenorhabditis elegans / genetics* Chromatin / genetics Chromatin / physiology* Gene Silencing RNA Interference* RNA, Double-Stranded Repetitive Sequences, Nucleic Acid* Transcription, Genetic |
| IF | 9.527 |
| 引用数 | 109 |
| WOS 分野 | GENETICS & HEREDITY DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 線虫 | tm1021 tm329 |