RRC ID 435
Author Robert VJ, Sijen T, van Wolfswinkel J, Plasterk RH.
Title Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences.
Journal Genes Dev
Abstract Protection of genomes against invasion by repetitive sequences, such as transposons, viruses, and repetitive transgenes, involves strong and selective silencing of these sequences. During silencing of repetitive transgenes, a trans effect ("cosuppression") occurs that results in silencing of cognate endogenous genes. Here we report RNA interference (RNAi) screens performed to catalog genes required for cosuppression in the Caenorhabditis elegans germline. We find factors with a putative role in chromatin remodeling and factors involved in RNAi. Together with molecular data also presented in this study, these results suggest that in C. elegans repetitive sequences trigger transcriptional gene silencing using RNAi and chromatin factors.
Volume 19(7)
Pages 782-7
Published 2005-4-1
DOI 10.1101/gad.332305
PII gad.332305
PMID 15774721
PMC PMC1074315
MeSH Animals Caenorhabditis elegans / genetics* Chromatin / genetics Chromatin / physiology* Gene Silencing RNA Interference* RNA, Double-Stranded Repetitive Sequences, Nucleic Acid* Transcription, Genetic
IF 9.527
Times Cited 109
C.elegans tm1021 tm329