論文 - 詳細
| RRC ID | 43712 |
|---|---|
| 著者 | Yamauchi Y, Izumi Y, Asakura K, Hayashi Y, Nomori H. |
| タイトル | Curcumin induces autophagy in ACC-MESO-1 cells. |
| ジャーナル | Phytother Res |
| Abstract |
Malignant pleural mesothelioma is known to be widely resistant to therapy and new treatment strategies are needed. Curcumin, which has a long history as a dietary spice is known to suppress the growth of multiple cancer lines, but the effects on mesothelioma cells are not well defined. In the present study we examined the effects of curcumin on ACC-MESO-1, which is a human derived mesothelioma cell line. We found that curcumin dose-dependently reduced cell viability but did not induce apoptosis. Curcumin administration increased LC3B-II/LC3B-I expression, and induced the formation of autophagosomes on electron microscopy. These changes were attenuated by RNA silencing of atg5. From these findings it was speculated that induction of autophagy was at least in part involved in the reduction of cell viability by curcumin. |
| 巻・号 | 26(12) |
| ページ | 1779-83 |
| 公開日 | 2012-12-1 |
| DOI | 10.1002/ptr.4645 |
| PMID | 22388865 |
| MeSH | Autophagy / drug effects* Autophagy-Related Protein 5 Cell Line, Tumor Cell Survival / drug effects* Curcumin / pharmacology* Dose-Response Relationship, Drug Gene Silencing Humans Mesothelioma / pathology* Microscopy, Electron, Transmission Microtubule-Associated Proteins / genetics RNA, Small Interfering |
| IF | 4.087 |
| 引用数 | 32 |
| WOS 分野 | CHEMISTRY, MEDICINAL PHARMACOLOGY & PHARMACY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | ACC-MESO-1(RCB2292) |