論文 - 詳細
| RRC ID | 43928 |
|---|---|
| 著者 | Eitsuka T, Nakagawa K, Ono Y, Tatewaki N, Nishida H, Kurata T, Shoji N, Miyazawa T. |
| タイトル | Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells. |
| ジャーナル | FEBS Lett |
| Abstract |
Several lines of experimental data have highlighted a key role of Amadori-glycated phosphatidylethanolamine (Amadori-PE) in the development of diabetic complications. Recent epidemiological studies suggest that diabetes mellitus could be a risk factor for some cancers. A characteristic of cancer cells is their immortal phenotype, and the enzyme telomerase contributes to the infinite replicative potential of cancer cells. The purpose of this study was to obtain new information about the effect of Amadori-PE on the regulation of telomerase in PANC-1 human pancreatic carcinoma cells. Amadori-PE enhanced cellular telomerase in a time- and dose-dependent manner by up-regulating hTERT expression through induction of c-myc. These results provide experimental evidence for a novel role of Amadori-PE in linking diabetes and cancer. |
| 巻・号 | 586(16) |
| ページ | 2542-7 |
| 公開日 | 2012-7-30 |
| DOI | 10.1016/j.febslet.2012.06.027 |
| PII | S0014-5793(12)00505-4 |
| PMID | 22750441 |
| MeSH | Carcinoma / metabolism* Cell Line, Tumor Disease Progression Dose-Response Relationship, Drug Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic* Glycolipids / pharmacology* Humans Lipids / chemistry Models, Chemical Pancreatic Neoplasms / metabolism* Phenotype Phosphatidylethanolamines / pharmacology* RNA, Messenger / metabolism Telomerase / biosynthesis* Telomerase / metabolism Tetrazolium Salts / pharmacology Thiazoles / pharmacology Time Factors Up-Regulation* |
| IF | 3.057 |
| 引用数 | 5 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PANC-1(RCB2095) |