| RRC ID |
43
|
| Author |
Ikeda K, Kitamura A, Machida H, Watanabe M, Negishi H, Hiraoka J, Nakano T.
|
| Title |
Effect of Undaria pinnatifida (Wakame) on the development of cerebrovascular diseases in stroke-prone spontaneously hypertensive rats.
|
| Journal |
Clin Exp Pharmacol Physiol
|
| Abstract |
1. We showed that a nutritional factor was able to attenuate the development of hypertension and its related diseases in stroke-prone spontaneously hypertensive rats (SHRSP). In the present study, the effect of Wakame, an edible brown seaweed, on the development of stroke was examined in SHRSP. 2. We studied the treatment with 5% (w/w in a diet) Wakame powder in salt-loaded (0.5% NaCl in drinking water) SHRSP. Salt-loaded animals treated with 5% cellulose or kaolin were used as controls. Wakame significantly delayed the development of stroke signs (P < 0.05) and significantly improved the survival rate of salt-loaded SHRSP (P < 0.05). There was no significant difference in the elevation of blood pressure among the three groups during the observation period. 3. We isolated fucoxanthin, a carotinoid, from Wakame powder and studied its preventive effect on ischaemic cultured neuronal cell death. Fucoxanthin significantly attenuated neuronal cell injury in hypoxia and re-oxygenation (P < 0.05). 4. Based on these results, we conclude that Wakame has a beneficial effect on cerebrovascular diseases in SHRSP, independent of hypertension. It is possible that fucoxanthin in Wakame may have a preventive effect against ischaemic neuronal cell death seen in SHRSP with stroke.
|
| Volume |
30(1-2)
|
| Pages |
44-8
|
| Published |
2003-1-1
|
| DOI |
10.1046/j.1440-1681.2003.03786.x
|
| PII |
3786
|
| PMID |
12542452
|
| MeSH |
Animals
Blood Pressure / drug effects
Body Weight / drug effects
Brain Ischemia / complications
Brain Ischemia / pathology
Brain Ischemia / prevention & control
Cell Death / drug effects
Cells, Cultured
Eukaryota / chemistry*
Hypertension / chemically induced
Hypertension / complications
Hypertension / physiopathology
Hypertension / prevention & control
Hypoxia, Brain / complications
Hypoxia, Brain / pathology
Hypoxia, Brain / prevention & control
Neurons / drug effects
Neurons / pathology
Plant Extracts / chemistry
Plant Extracts / pharmacology*
Rats
Rats, Inbred SHR
Sodium Chloride / pharmacology
Stroke / chemically induced
Stroke / complications
Stroke / physiopathology
Stroke / prevention & control*
Xanthophylls / analysis
Xanthophylls / pharmacology
|
| IF |
2.456
|
| Times Cited |
64
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
PHYSIOLOGY
|
| Resource |
| Rats |
SHRSP/Izm(strainID=409) |
