RRC ID |
44
|
著者 |
Inoue S, Tahara K, Shimizu H, Yoshino H, Suzuki C, Kaneko T, Hakamata Y, Takahashi M, Murakami T, Kaneko M, Kobayashi E.
|
タイトル |
Rat liver transplantation for total vascular reconstruction, using a suture method.
|
ジャーナル |
Microsurgery
|
Abstract |
We developed a novel protocol for rat orthotopic liver transplantation (OLT), using a suture method to establish hepatic artery flow. After determining that early inferior vena cava (IVC) unclamping maintained better circulation compared with the portal vein (PV) using porto-systemic shunted recipients, we developed a rat OLT model with total vascular reconstruction using a suture method. After connecting the suprahepatic IVC, the infrahepatic IVC was anastomosed, using a running suture method. IVC circulation was established immediately. The PV was anastomosed without intestinal congestion, using porto-systemic shunted recipients. The aortic conduit, including the donor celiac and hepatic artery, was anastomosed to the recipient abdominal aorta end-to-side. Eight of 11 OLT cases (72.7%) survived indefinitely. Biliary connection was achieved using a one-stent method. Three cases died 3-5 days postoperatively. Hepatic angiography showed good patency. The graft liver was histologically normal in long-surviving rats.
|
巻・号 |
23(5)
|
ページ |
470-5
|
公開日 |
2003-1-1
|
DOI |
10.1002/micr.10168
|
PMID |
14558005
|
MeSH |
Animals
Aorta / surgery
Celiac Artery / surgery
Hemodynamics / physiology
Hepatic Artery / surgery
Liver Transplantation / methods*
Models, Animal
Portal Vein / surgery
Rats
Rats, Inbred Lew
Suture Techniques*
Vascular Surgical Procedures / methods*
Vena Cava, Inferior / surgery
|
IF |
1.996
|
引用数 |
16
|
WOS 分野
|
SURGERY
|
リソース情報 |
ラット |
|