RRC ID 44003
著者 Kwon HJ.
タイトル ATP oscillations mediate inductive action of FGF and Shh signalling on prechondrogenic condensation.
ジャーナル Cell Biochem Funct
Abstract Skeletal patterns are prefigured by prechondrogenic condensation. Morphogens such as fibroblast growth factor (FGF) and sonic hedgehog (Shh) specify the skeletal patterns in limb development. However, how morphogens regulate prechondrogenic condensation has remained unclear. Recently, it was demonstrated that synchronized Adenosine triphosphate (ATP) oscillations play a critical role in prechondrogenic condensation. Thus, the present study has focused on whether ATP oscillations mediate the actions of major developmental morphogens such as FGF and Shh on prechondrogenic condensation. It has been shown that both FGF and Shh signalling promoted cellular condensation but not chondrogenic differentiation and also induced ATP oscillations. In addition, blockage of FGF and Shh signalling prevented both ATP oscillations and prechondrogenic condensation. Furthermore, it was found that inhibition of ATP oscillations suppressed FGF/Shh-induced prechondrogenic condensation. These results indicate that ATP oscillations mediate the actions of FGF and Shh signalling on prechondrogenic condensation. This study proposes that morphogens organize skeletal patterns via ATP oscillations.
巻・号 31(1)
ページ 75-81
公開日 2013-1-1
DOI 10.1002/cbf.2862
PMID 22886426
MeSH Adenosine Triphosphate / physiology* Animals Cell Line / drug effects Chondrocytes / cytology Chondrocytes / drug effects* Chondrogenesis / drug effects Chondrogenesis / physiology* Cinnamates / pharmacology Fibroblast Growth Factor 2 / antagonists & inhibitors Fibroblast Growth Factor 2 / physiology* Gene Expression Regulation, Developmental / drug effects Genes, Reporter Hedgehog Proteins / antagonists & inhibitors Hedgehog Proteins / physiology* Insulin / pharmacology Luminescent Measurements Mice Pyrroles / pharmacology Signal Transduction / drug effects Signal Transduction / physiology Transfection Veratrum Alkaloids / pharmacology
IF 2.632
引用数 9
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
ヒト・動物細胞 ATDC5(RCB0565)