| RRC ID |
44243
|
| 著者 |
Goto H, Matsuda K, Srikoon P, Kariya R, Hattori S, Taura M, Katano H, Okada S.
|
| タイトル |
Potent antitumor activity of zoledronic acid-induced Vγ9Vδ2 T cells against primary effusion lymphoma.
|
| ジャーナル |
Cancer Lett
|
| Abstract |
Primary effusion lymphoma (PEL) is a subtype of aggressive and resistant non-Hodgkin lymphoma that occurs predominantly in patients with advanced AIDS. In this study, we examined the antitumor activity of zoledronic acid (Zol)-induced Vγ9Vδ2 T cells against PEL cells in vitro and in vivo. Vγ9Vδ2 T cells recognized endogenous mevalonate metabolites and MICA/B of PEL cell lines, inducing cytotoxicity via granule exocytosis and TRAIL-mediated pathway. Vγ9Vδ2 T cells suppressed the development of PEL cells and existed in a PEL xenograft mouse model. These results show that immunotherapy with Zol-induced Vγ9Vδ2 T cells could demonstrate an efficient strategy for PEL.
|
| 巻・号 |
331(2)
|
| ページ |
174-82
|
| 公開日 |
2013-5-1
|
| DOI |
10.1016/j.canlet.2012.12.021
|
| PII |
S0304-3835(13)00005-0
|
| PMID |
23321500
|
| MeSH |
Animals
Cell Proliferation / drug effects
Diphosphonates / pharmacology
Diphosphonates / therapeutic use*
Flow Cytometry
Humans
Imidazoles / pharmacology
Imidazoles / therapeutic use*
Immunohistochemistry
Lymphoma, Primary Effusion / immunology
Lymphoma, Primary Effusion / therapy*
Mice
Mice, Inbred NOD
T-Lymphocytes / cytology
T-Lymphocytes / drug effects*
T-Lymphocytes / immunology
Xenograft Model Antitumor Assays
Zoledronic Acid
|
| IF |
7.36
|
| 引用数 |
9
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
DAUDI(RCB1640) |
