論文 - 詳細
| RRC ID | 44243 |
|---|---|
| 著者 | Goto H, Matsuda K, Srikoon P, Kariya R, Hattori S, Taura M, Katano H, Okada S. |
| タイトル | Potent antitumor activity of zoledronic acid-induced Vγ9Vδ2 T cells against primary effusion lymphoma. |
| ジャーナル | Cancer Lett |
| Abstract |
Primary effusion lymphoma (PEL) is a subtype of aggressive and resistant non-Hodgkin lymphoma that occurs predominantly in patients with advanced AIDS. In this study, we examined the antitumor activity of zoledronic acid (Zol)-induced Vγ9Vδ2 T cells against PEL cells in vitro and in vivo. Vγ9Vδ2 T cells recognized endogenous mevalonate metabolites and MICA/B of PEL cell lines, inducing cytotoxicity via granule exocytosis and TRAIL-mediated pathway. Vγ9Vδ2 T cells suppressed the development of PEL cells and existed in a PEL xenograft mouse model. These results show that immunotherapy with Zol-induced Vγ9Vδ2 T cells could demonstrate an efficient strategy for PEL. |
| 巻・号 | 331(2) |
| ページ | 174-82 |
| 公開日 | 2013-5-1 |
| DOI | 10.1016/j.canlet.2012.12.021 |
| PII | S0304-3835(13)00005-0 |
| PMID | 23321500 |
| MeSH | Animals Cell Proliferation / drug effects Diphosphonates / pharmacology Diphosphonates / therapeutic use* Flow Cytometry Humans Imidazoles / pharmacology Imidazoles / therapeutic use* Immunohistochemistry Lymphoma, Primary Effusion / immunology Lymphoma, Primary Effusion / therapy* Mice Mice, Inbred NOD T-Lymphocytes / cytology T-Lymphocytes / drug effects* T-Lymphocytes / immunology Xenograft Model Antitumor Assays Zoledronic Acid |
| IF | 7.36 |
| 引用数 | 9 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | DAUDI(RCB1640) |