Reference - Detail
| RRC ID | 44290 |
|---|---|
| Author | Liu H, Han D, Liu Y, Hou X, Wu J, Li H, Yang J, Shen C, Yang G, Fu C, Li X, Che H, Ai J, Zhao S. |
| Title | Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma. |
| Journal | J Neurooncol |
| Abstract |
Harmine hydrochloride (Har-hc), a derivative from Harmine which is a natural extractive from plants, has been considered for treatment of kinds of cancers and cerebral diseases. In this study, we found that Har-hc clearly decreased cell viability, induced apoptosis and inhibited Akt phosphorylation in glioblastoma cell lines. Moreover, Har-hc had the ability to inhibit self-renewal and promote differentiation of glioblastoma stem like cells (GSLCs) accompanied by inhibition of Akt phosphorylation. Especially, we demonstrated that Har-hc inhibited neurosphere formation of human primary GSLCs. In vivo test also confirmed Har-hc decreased the tumorigenicity of GSLCs. Thus we conclude that Har-hc has potent anti-cancer effects in glioblastoma cells, which is at least partially via inhibition of Akt phosphorylation. Administration of Har-hc may act as a new approach to glioblastoma treatment. |
| Volume | 112(1) |
| Pages | 39-48 |
| Published | 2013-3-1 |
| DOI | 10.1007/s11060-012-1034-x |
| PMID | 23392846 |
| MeSH | Analysis of Variance Animals Apoptosis / drug effects Brain / drug effects Brain / pathology Cell Differentiation / drug effects Cell Line, Tumor Cell Proliferation / drug effects* Chromones / pharmacology Dose-Response Relationship, Drug Enzyme Inhibitors / pharmacology Gene Expression Regulation, Neoplastic / drug effects Glioblastoma / pathology* Harmine / pharmacology* Humans Monoamine Oxidase Inhibitors / pharmacology* Morpholines / pharmacology Neoplastic Stem Cells / drug effects* Neoplastic Stem Cells / pathology Nerve Tissue Proteins / metabolism Oncogene Protein v-akt / genetics Oncogene Protein v-akt / metabolism Phosphorylation / drug effects Proto-Oncogene Proteins c-bcl-2 / genetics Proto-Oncogene Proteins c-bcl-2 / metabolism Signal Transduction Time Factors bcl-2-Associated X Protein / genetics bcl-2-Associated X Protein / metabolism |
| IF | 3.267 |
| Times Cited | 18 |
| WOS Category | CLINICAL NEUROLOGY ONCOLOGY |
| Resource | |
| Human and Animal Cells | |