RRC ID |
44385
|
著者 |
Kumano-Kuramochi M, Xie Q, Kajiwara S, Komba S, Minowa T, Machida S.
|
タイトル |
Lectin-like oxidized LDL receptor-1 is palmitoylated and internalizes ligands via caveolae/raft-dependent endocytosis.
|
ジャーナル |
Biochem Biophys Res Commun
|
Abstract |
Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is an endothelial scavenger receptor that is important for oxidized low-density lipoprotein uptake. LOX-1 functions as an oligomer; however, little is known about the oligomeric complex and ligand processing after recognition by LOX-1. Here, we found that LOX-1 recognized and internalized ligands through the caveolae/raft-dependent endocytosis pathway in human coronary artery endothelial cells. Furthermore, we demonstrated that LOX-1 was palmitoylated and that both cysteine 36 and cysteine 46 were necessary for the recruitment of LOX-1 into raft microdomains and for its ligand uptake ability.
|
巻・号 |
434(3)
|
ページ |
594-9
|
公開日 |
2013-5-10
|
DOI |
10.1016/j.bbrc.2013.03.120
|
PII |
S0006-291X(13)00599-8
|
PMID |
23583401
|
MeSH |
Caveolae / metabolism*
Cells, Cultured
Endocytosis* / drug effects
Genistein / pharmacology
Humans
Ligands
Lipoylation
Nystatin / pharmacology
Scavenger Receptors, Class E / metabolism*
|
IF |
2.985
|
引用数 |
7
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
ヒト・動物細胞 |
|