論文 - 詳細
| RRC ID | 44385 |
|---|---|
| 著者 | Kumano-Kuramochi M, Xie Q, Kajiwara S, Komba S, Minowa T, Machida S. |
| タイトル | Lectin-like oxidized LDL receptor-1 is palmitoylated and internalizes ligands via caveolae/raft-dependent endocytosis. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is an endothelial scavenger receptor that is important for oxidized low-density lipoprotein uptake. LOX-1 functions as an oligomer; however, little is known about the oligomeric complex and ligand processing after recognition by LOX-1. Here, we found that LOX-1 recognized and internalized ligands through the caveolae/raft-dependent endocytosis pathway in human coronary artery endothelial cells. Furthermore, we demonstrated that LOX-1 was palmitoylated and that both cysteine 36 and cysteine 46 were necessary for the recruitment of LOX-1 into raft microdomains and for its ligand uptake ability. |
| 巻・号 | 434(3) |
| ページ | 594-9 |
| 公開日 | 2013-5-10 |
| DOI | 10.1016/j.bbrc.2013.03.120 |
| PII | S0006-291X(13)00599-8 |
| PMID | 23583401 |
| MeSH | Caveolae / metabolism* Cells, Cultured Endocytosis* / drug effects Genistein / pharmacology Humans Ligands Lipoylation Nystatin / pharmacology Scavenger Receptors, Class E / metabolism* |
| IF | 2.985 |
| 引用数 | 7 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | CHO |