論文 - 詳細
| RRC ID | 44548 |
|---|---|
| 著者 | Tanaka Y, Suenaga T, Matsumoto M, Seya T, Arase H. |
| タイトル | Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion. |
| ジャーナル | J Virol |
| Abstract |
The human herpesvirus 6 (HHV-6) envelope glycoprotein gH/gL/gQ1/gQ2 complex associates with host cell CD46 as its cellular receptor. Although gB has been suggested to be involved in HHV-6 infection, its function in membrane fusion has remained unclear. Here, we have developed an HHV-6A (strain GS)and HHV-6B (strain Z29) virus-free cell-to-cell fusion assay and demonstrate that gB and the gH/gL/gQ1/gQ2 complex are the minimum components required for membrane fusion by HHV-6. |
| 巻・号 | 87(19) |
| ページ | 10900-3 |
| 公開日 | 2013-10-1 |
| DOI | 10.1128/JVI.01427-13 |
| PII | JVI.01427-13 |
| PMID | 23885076 |
| PMC | PMC3807422 |
| MeSH | Cell Fusion* Cells, Cultured DNA, Viral / genetics Flow Cytometry Glycoproteins / classification Glycoproteins / genetics Glycoproteins / metabolism* Herpesviridae Infections / genetics Herpesviridae Infections / metabolism* Herpesviridae Infections / virology Herpesvirus 6, Human / physiology* Humans Kidney / cytology Kidney / metabolism Kidney / virology Luciferases / metabolism Membrane Cofactor Protein / genetics Membrane Cofactor Protein / metabolism* Membrane Fusion* Polymerase Chain Reaction |
| IF | 4.501 |
| 引用数 | 12 |
| WOS 分野 | VIROLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | |