RRC ID 44548
Author Tanaka Y, Suenaga T, Matsumoto M, Seya T, Arase H.
Title Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion.
Journal J Virol
Abstract The human herpesvirus 6 (HHV-6) envelope glycoprotein gH/gL/gQ1/gQ2 complex associates with host cell CD46 as its cellular receptor. Although gB has been suggested to be involved in HHV-6 infection, its function in membrane fusion has remained unclear. Here, we have developed an HHV-6A (strain GS)and HHV-6B (strain Z29) virus-free cell-to-cell fusion assay and demonstrate that gB and the gH/gL/gQ1/gQ2 complex are the minimum components required for membrane fusion by HHV-6.
Volume 87(19)
Pages 10900-3
Published 2013-10-1
DOI 10.1128/JVI.01427-13
PII JVI.01427-13
PMID 23885076
PMC PMC3807422
MeSH Cell Fusion* Cells, Cultured DNA, Viral / genetics Flow Cytometry Glycoproteins / classification Glycoproteins / genetics Glycoproteins / metabolism* Herpesviridae Infections / genetics Herpesviridae Infections / metabolism* Herpesviridae Infections / virology Herpesvirus 6, Human / physiology* Humans Kidney / cytology Kidney / metabolism Kidney / virology Luciferases / metabolism Membrane Cofactor Protein / genetics Membrane Cofactor Protein / metabolism* Membrane Fusion* Polymerase Chain Reaction
IF 4.324
Times Cited 12
Human and Animal Cells