論文 - 詳細
| RRC ID | 44600 |
|---|---|
| 著者 | Matsuzaki J, Torigoe T, Hirohashi Y, Tamura Y, Asanuma H, Nakazawa E, Saka E, Yasuda K, Takahashi S, Sato N. |
| タイトル | Expression of ECRG4 is associated with lower proliferative potential of esophageal cancer cells. |
| ジャーナル | Pathol Int |
| Abstract |
We have shown that ECRG4 suppressed Fas-induced apoptosis in Jurkat cells. ECRG4 mRNA expression was ubiquitously detected in normal adult human tissues, suggesting that ECRG4 plays a major role in human tissues. ECRG4 mRNA expression was down-regulated in tumor cells. Expression of ECRG4 suppressed cell growth. We established an anti-ECRG4 monoclonal antibody. Our immunohistochemical analysis demonstrated that ECRG4-positive cells tended to be distributed in the region that was negative for Ki-67 in esophageal squamous cell carcinoma tissues. There was a significant inverse correlation between ECRG4 expression and Ki-67 labeling index in esophageal squamous cell carcinoma. This study provides the first functional evidence for an association of endogenous expression of ECRG4 with cell proliferation. ECRG4 is a candidate tumor suppressor gene that might be involved in the proliferation of esophageal squamous cell carcinoma. |
| 巻・号 | 63(8) |
| ページ | 391-7 |
| 公開日 | 2013-8-1 |
| DOI | 10.1111/pin.12079 |
| PMID | 23957914 |
| MeSH | Aged Antibodies, Monoclonal / immunology* Carcinoma, Squamous Cell / metabolism* Carcinoma, Squamous Cell / pathology Cell Line, Tumor Cell Proliferation Esophageal Neoplasms / metabolism* Esophageal Neoplasms / pathology Esophageal Squamous Cell Carcinoma Female Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Ki-67 Antigen / metabolism Male Middle Aged Neoplasm Proteins / genetics Neoplasm Proteins / immunology Neoplasm Proteins / metabolism* Prognosis RNA, Messenger / metabolism Tumor Suppressor Proteins / genetics Tumor Suppressor Proteins / immunology Tumor Suppressor Proteins / metabolism* |
| IF | 2.11 |
| 引用数 | 19 |
| WOS 分野 | PATHOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | TE-8(RCB20989 |