RRC ID 44771
Author Tamaki M, Miyashita K, Wakino S, Mitsuishi M, Hayashi K, Itoh H.
Title Chronic kidney disease reduces muscle mitochondria and exercise endurance and its exacerbation by dietary protein through inactivation of pyruvate dehydrogenase.
Journal Kidney Int
Abstract Chronic kidney disease impairs physical performance. Here the time course and mechanism of muscle insufficiency in renal failure and the influence of dietary protein were studied using 5/6 nephrectomized C57Bl/6 mice, focusing on muscle mass and mitochondria. A decrease in muscle mitochondria and running distance was found in young (16-20 weeks) 5/6 nephrectomized mice, despite the preservation of muscle volume and power. However, a decrease in muscle volume, associated with a reduction in muscle power, was found in aged (48-52 weeks) 5/6 nephrectomized mice. A high-protein diet feeding from 8 weeks increased muscle volume and power in the mice; but this further decreased running distance. Activation of pyruvate dehydrogenase by dichloroacetate effectively recovered running distance that was decreased by dietary protein. These findings indicate the mechanism of muscle insufficiency in renal failure and suggest that activation of muscle mitochondria would serve as a potential strategy for improving the physical performance of the patients with chronic kidney disease.
Volume 85(6)
Pages 1330-9
Published 2014-6-1
DOI 10.1038/ki.2013.473
PII S0085-2538(15)56359-X
PMID 24284514
MeSH Animals Cytokines / metabolism Dichloroacetic Acid / pharmacology Dietary Proteins / adverse effects* Dietary Proteins / metabolism Disease Models, Animal Enzyme Activation Enzyme Activators / pharmacology Exercise Tolerance* / drug effects Inflammation Mediators / metabolism Male Mice, Inbred C57BL Mitochondria, Muscle / drug effects Mitochondria, Muscle / enzymology* Mitochondrial Turnover* / drug effects Muscle Strength Muscle, Skeletal / drug effects Muscle, Skeletal / enzymology* Muscle, Skeletal / pathology Muscle, Skeletal / physiopathology Oxidative Stress Pyruvate Dehydrogenase Complex / metabolism* Renal Insufficiency, Chronic / complications Renal Insufficiency, Chronic / enzymology* Renal Insufficiency, Chronic / physiopathology Renal Insufficiency, Chronic / therapy Running Signal Transduction / drug effects Time Factors
IF 8.945
Times Cited 53
Human and Animal Cells C2C12(RCB0987)