| RRC ID |
44875
|
| 著者 |
Kimura T, Kato E, Machikawa T, Kimura S, Katayama S, Kawabata J.
|
| タイトル |
Hydroxylamine enhances glucose uptake in C2C12 skeletal muscle cells through the activation of insulin receptor substrate 1.
|
| ジャーナル |
Biochem Biophys Res Commun
|
| Abstract |
Diabetes mellitus is a global disease, and the number of patients with it is increasing. Of various agents for treatment, those that directly act on muscle are currently attracting attention because muscle is one of the main tissues in the human body, and its metabolism is decreased in type II diabetes. In this study, we found that hydroxylamine (HA) enhances glucose uptake in C2C12 myotubes. Analysis of HA's mechanism revealed the involvement of IRS1, PI3K and Akt that is related to the insulin signaling pathway. Further investigation about the activation mechanism of insulin receptor or IRS1 by HA may provide a way to develop a novel anti-diabetic agent alternating to insulin.
|
| 巻・号 |
445(1)
|
| ページ |
6-9
|
| 公開日 |
2014-2-28
|
| DOI |
10.1016/j.bbrc.2014.01.039
|
| PII |
S0006-291X(14)00063-1
|
| PMID |
24462868
|
| MeSH |
Animals
Blotting, Western
Cell Line
Glucose / pharmacokinetics*
Humans
Hydroxylamine / pharmacology*
Hypoglycemic Agents / pharmacology
Insulin / pharmacology
Insulin Receptor Substrate Proteins / metabolism*
Mice
Muscle Fibers, Skeletal / cytology
Muscle Fibers, Skeletal / drug effects*
Muscle Fibers, Skeletal / metabolism
Phosphatidylinositol 3-Kinases / metabolism
Phosphorylation / drug effects
Proto-Oncogene Proteins c-akt / metabolism
Signal Transduction / drug effects
|
| IF |
2.985
|
| 引用数 |
5
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
C2C12(RCB0987) |
