論文 - 詳細
| RRC ID | 44966 |
|---|---|
| 著者 | Jambalganiin U, Tsolmongyn B, Koide N, Odkhuu E, Naiki Y, Komatsu T, Yoshida T, Yokochi T. |
| タイトル | A novel mechanism for inhibition of lipopolysaccharide-induced proinflammatory cytokine production by valproic acid. |
| ジャーナル | Int Immunopharmacol |
| Abstract |
The inhibitory effect of valproic acid (VPA) on lipopolysaccharide (LPS)-induced inflammatory response was studied by using mouse RAW 264.7 macrophage-like cells. VPA pretreatment attenuated LPS-induced phosphorylation of phosphatidylinositol 3-kinase (PI3K) and Akt, but not nuclear factor (NF)-κB and mitogen-activated protein kinases. VPA reduced phosphorylation of MDM2, an ubiquitin ligase and then prevented LPS-induced p53 degradation, followed by enhanced p53 expression. Moreover, p53 small interfering RNA (siRNA) abolished the inhibitory action of VPA on LPS-induced NF-κB p65 transcriptional activation and further LPS-induced tumor necrosis factor (TNF)-α and interleukin (IL)-6 production. VPA prevented LPS-induced degradation of phosphatase and tensin homologue deleted on chromosome ten (PTEN) and up-regulated the PTEN expression. Taken together, VPA was suggested to down-regulate LPS-induced NF-κB-dependent transcriptional activity via impaired PI3K/Akt/MDM2 activation and enhanced p53 expression. A detailed mechanism for inhibition of LPS-induced inflammatory response by VPA is discussed. |
| 巻・号 | 20(1) |
| ページ | 181-7 |
| 公開日 | 2014-5-1 |
| DOI | 10.1016/j.intimp.2014.02.032 |
| PII | S1567-5769(14)00086-1 |
| PMID | 24631367 |
| MeSH | Animals Anti-Inflammatory Agents / pharmacology* Cell Line Interleukin-6 / antagonists & inhibitors* Interleukin-6 / metabolism Lipopolysaccharides Mice Mitogen-Activated Protein Kinases / metabolism NF-kappa B / metabolism PTEN Phosphohydrolase / metabolism Phosphatidylinositol 3-Kinases / metabolism Proto-Oncogene Proteins c-akt / metabolism Toll-Like Receptor 4 / metabolism Tumor Necrosis Factor-alpha / antagonists & inhibitors* Tumor Necrosis Factor-alpha / metabolism Tumor Suppressor Protein p53 / metabolism Valproic Acid / pharmacology* |
| IF | 3.943 |
| 引用数 | 10 |
| WOS 分野 | PHARMACOLOGY & PHARMACY IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |