論文 - 詳細
| RRC ID | 45013 |
|---|---|
| 著者 | Zhao W, Zhang Y, Liu D, Zhong L, He Q, Zhao Y. |
| タイトル | Abnormal expression of CD66a promotes proliferation and inhibits apoptosis of human leukemic B cells in vitro. |
| ジャーナル | Leuk Lymphoma |
| Abstract |
The aberrant expression of myeloid antigen CD66 on acute B-lymphoblastic leukemia (B-ALL) cells is a well-documented phenomenon. CD66a is a major subtype of the CD66 family which plays a dual role in different cancers, and the contradictory effect may depend on the isoform ratio of CD66a-4L to CD66a-4S. Although the abnormal expression of CD66a on leukemic B-cells has been reported widely, little is known about the biological function of this aberrant expression. In this study, we showed that inhibition of CD66a in human B-ALL cell lines reduced the cellular proliferative rate and increased the percentage of cellular apoptosis, and the ratio of CD66a-4L to CD66a-4S in leukemic B cells is much higher than that in granulocytes. In addition, alteration of the L:S ratio by silencing and overexpressing the L isoform in B-ALL cell lines confirmed that a high L:S ratio of CD66a in leukemic B cells promotes proliferation and inhibits FasL-induced apoptosis. |
| 巻・号 | 56(1) |
| ページ | 202-10 |
| 公開日 | 2015-1-1 |
| DOI | 10.3109/10428194.2014.913287 |
| PMID | 24716460 |
| MeSH | Antigens, CD / genetics* Antigens, CD / metabolism Apoptosis / genetics* Caspases / metabolism Cell Adhesion Molecules / genetics* Cell Adhesion Molecules / metabolism Cell Line, Tumor Cell Membrane / metabolism Cell Proliferation Fas Ligand Protein / genetics Fas Ligand Protein / metabolism Gene Expression* Granulocytes / metabolism Humans Leukemia, B-Cell / genetics* Leukemia, B-Cell / metabolism Protein Isoforms RNA Interference RNA, Small Interfering / genetics |
| IF | 2.969 |
| 引用数 | 2 |
| WOS 分野 | HEMATOLOGY ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | BALL-1 |