RRC ID 45030
Author Yang XQ, Xu YF, Guo S, Liu Y, Ning SL, Lu XF, Yang H, Chen YX.
Title Clinical significance of nerve growth factor and tropomyosin-receptor-kinase signaling pathway in intrahepatic cholangiocarcinoma.
Journal World J Gastroenterol
Abstract AIM:To investigate the correlation between nerve growth factor-tropomyosin-receptor-kinase (NGF-TrkA) signaling pathway and prognosis in intrahepatic cholangiocarcinoma (IHCC).
METHODS:NGF and TrkA expression in 83 samples of IHCC was assessed by immunohistochemistry. Correlations between NGF-TrkA expression and clinicopathological features were analyzed by χ² test. Moreover, we evaluated the association between NGF-TrkA and overall survival by univariate and multivariate analysis. With experiments in vitro, we investigated the crucial role of NGF-TrkA on proliferation and invasion of IHCC cells with recombinant NGF-β stimulation.
RESULTS:We found that NGF and TrkA expression was significantly related with differentiation (P = 0.024) and intraneural invasion (P = 0.003), respectively. Additionally, double higher expression of NGF and TrkA was identified as an independent prognostic factor in IHCC (P = 0.003). Moreover, we demonstrated that NGF-TrkA signaling pathway can promote IHCC proliferation and invasion.
CONCLUSION:NGF-TrkA double higher expression is an independent prognostic factor in IHCC. NGF-TrkA pathway can promote IHCC progression, indicating that NGF-TrkA may become a potential drug target.
Volume 20(14)
Pages 4076-84
Published 2014-4-14
DOI 10.3748/wjg.v20.i14.4076
PMID 24744599
PMC PMC3983466
MeSH Aged Bile Duct Neoplasms / metabolism* Bile Ducts, Intrahepatic / metabolism* Cell Line, Tumor Cell Proliferation Cholangiocarcinoma / metabolism* Female Gene Expression Regulation, Neoplastic* Humans Immunohistochemistry Kaplan-Meier Estimate Male Middle Aged Multivariate Analysis Neoplasm Invasiveness Neoplasm Metastasis Neoplasm Staging Nerve Growth Factor / metabolism* Prognosis Receptor, trkA / metabolism* Signal Transduction Treatment Outcome
IF 3.411
Times Cited 27
Human and Animal Cells