RRC ID 45066
著者 Takei T, Kitazono J, Tanaka S, Nishimata H, Yoshida M.
タイトル Necrotic regions are absent in fiber-shaped cell aggregates, approximately 100 μm in diameter.
ジャーナル Artif Cells Nanomed Biotechnol
Abstract Microscopic, fiber-shaped cell aggregates, have been used as building blocks for fabricating macroscopic three-dimensional tissue architectures, in the field of tissue engineering. In this study, we examined the occurrence of necrotic regions in the most widely used, fiber-shaped cell aggregates, approximately 100 μm in diameter. Alginate hydrogel hollow microfibers were used as templates for the cell aggregates. We demonstrated negligible necrotic region formation occurred in the cell aggregates formed in the hollow microfibers. Furthermore, we improved on previously-reported methods for preparing the hollow microfibers to avoid common microfiber tangling during the fiber preparation process.
巻・号 44(1)
ページ 62-5
公開日 2016-1-1
DOI 10.3109/21691401.2014.909824
PMID 24813225
MeSH Alginates / chemistry* Cell Aggregation Glucuronic Acid / chemistry Hep G2 Cells Hexuronic Acids / chemistry Humans Hydrogels / chemistry* Necrosis / prevention & control Tissue Engineering
IF 3.343
引用数 3
WOS 分野 ENGINEERING, BIOMEDICAL BIOTECHNOLOGY & APPLIED MICROBIOLOGY MATERIALS SCIENCE, BIOMATERIALS
リソース情報
ヒト・動物細胞 Hep G2(RCB1648)