論文 - 詳細
| RRC ID | 45338 |
|---|---|
| 著者 | Yoshikawa N, Shimizu N, Ojima H, Kobayashi H, Hosono O, Tanaka H. |
| タイトル | Down-regulation of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor by HEXIM1 attenuates myocardial angiogenesis in hypoxic mice. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Pulmonary hypertension (PH) sustains elevation of pulmonary vascular resistance and ultimately leads to right ventricular (RV) hypertrophy and failure and death. Recently, proangiogenic factors hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) have been known to promote left ventricular myocardial angiogenesis and lead to cardiac hypertrophy, and this would be involved in RV hypertrophy of PH patients. Previously, we revealed that overexpression of HEXIM1 prevents endothelin-1-induced cardiomyocyte hypertrophy and hypertrophic genes expression, and that cardiomyocyte-specific HEXIM1 transgenic mice ameliorates RV hypertrophy in hypoxia-induced PH model. Given these results, here we analyzed the effect of HEXIM1 on the expression of HIF-1α and VEGF and on myocardial angiogenesis of RV in PH. We revealed that overexpression of HEXIM1 prevented hypoxia-induced expression of HIF-1α protein and its target genes including VEGF in the cultured cardiac myocytes and fibroblasts, and that cardiomyocyte-specific HEXIM1 transgenic mice repressed RV myocardial angiogenesis in hypoxia-induced PH model. Thus, we conclude that HEXIM1 could prevent RV hypertrophy, at least in part, via suppression of myocardial angiogenesis through down-regulation of HIF-1α and VEGF in the myocardium under hypoxic condition. |
| 巻・号 | 453(3) |
| ページ | 600-5 |
| 公開日 | 2014-10-24 |
| DOI | 10.1016/j.bbrc.2014.09.135 |
| PII | S0006-291X(14)01778-1 |
| PMID | 25301555 |
| MeSH | Animals Coronary Vessels / growth & development* Down-Regulation* HeLa Cells Humans Hypoxia / physiopathology* Hypoxia-Inducible Factor 1, alpha Subunit / metabolism* Mice Mice, Transgenic Neovascularization, Pathologic / physiopathology* RNA-Binding Proteins Transcription Factors / genetics Transcription Factors / physiology* Vascular Endothelial Growth Factor A / metabolism* |
| IF | 2.985 |
| 引用数 | 4 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa |