RRC ID 45436
著者 Tang H, Mahmoud NF, Mori Y.
タイトル Maturation of human herpesvirus 6A glycoprotein O requires coexpression of glycoprotein H and glycoprotein L.
ジャーナル J Virol
Abstract Glycoprotein O (gO) is conserved among betaherpesviruses, but little is known about the maturation process of gO in human herpesvirus 6 (HHV-6). We found that HHV-6 gO maturation was accompanied by cleavage of its carboxyl terminus and required coexpression of gH and gL, which promoted the export of gO out of the endoplasmic reticulum (ER). Finally, we also found that gO was not required for HHV-6A growth in T cells.
巻・号 89(9)
ページ 5159-63
公開日 2015-5-1
DOI 10.1128/JVI.00140-15
PII JVI.00140-15
PMID 25694589
PMC PMC4403471
MeSH Cells, Cultured Gene Expression Herpesvirus 6, Human / physiology* Humans Protein Processing, Post-Translational* T-Lymphocytes / virology Viral Envelope Proteins / metabolism* Virus Replication*
IF 4.501
引用数 7
WOS 分野 VIROLOGY
リソース情報
研究用ヒト臍帯血幹細胞