論文 - 詳細
| RRC ID | 45470 |
|---|---|
| 著者 | Sakamoto K, Imai K, Higashi T, Taki K, Nakagawa S, Okabe H, Nitta H, Hayashi H, Chikamoto A, Ishiko T, Beppu T, Baba H. |
| タイトル | Significance of P-cadherin overexpression and possible mechanism of its regulation in intrahepatic cholangiocarcinoma and pancreatic cancer. |
| ジャーナル | Cancer Sci |
| Abstract |
It has become evident that P-cadherin, one of the classical cadherins, contributes to the malignant behavior of several types of cancer. In this study, we analyzed the expression of P-cadherin and its clinicopathological and prognostic values in intrahepatic cholangiocarcinoma (ICC) and pancreatic cancer. Furthermore, we investigated the functional role of P-cadherin in these cancer cells by knockdown and overexpression in vitro and by analyzing the correlation between the P-cadherin expression and its promoter methylation status. Thirty of 59 ICC cases (51%) and 36 of 73 pancreatic cancer cases (49%) stained positive for P-cadherin with mainly membranous distribution in tumor cells by immunohistochemistry. P-cadherin expression was significantly correlated with several clinicopathological factors, which reflect tumor behavior, and was identified as an independent adverse prognostic factor for disease-free survival in patients with ICC (relative risk [RR] 2.93, P = 0.04) and pancreatic cancer (RR 2.68, P = 0.005) via multivariate analyses. P-cadherin downregulation by siRNA suppressed migration and invasion, and P-cadherin overexpression induced the opposite effects in both ICC and pancreatic cancer cells, without any effects on cell proliferation. P-cadherin expression was related to its promoter methylation status in both cell lines and cancer tissues. In summary, P-cadherin overexpression may serve as a useful biomarker of invasive phenotype and poor prognosis; P-cadherin expression was found to be regulated by its promoter methylation. These results suggest that P-cadherin represents a novel therapeutic target for the treatment of ICC and pancreatic cancer. |
| 巻・号 | 106(9) |
| ページ | 1153-62 |
| 公開日 | 2015-9-1 |
| DOI | 10.1111/cas.12732 |
| PMID | 26132727 |
| PMC | PMC4582984 |
| MeSH | Aged Bile Duct Neoplasms / genetics* Bile Duct Neoplasms / pathology* Biomarkers, Tumor / genetics Cadherins / genetics* Cell Line, Tumor Cell Proliferation / genetics Cholangiocarcinoma / genetics* Cholangiocarcinoma / pathology* Disease-Free Survival Down-Regulation / genetics Female Gene Expression Regulation, Neoplastic / genetics Humans Male Pancreatic Neoplasms / genetics* Pancreatic Neoplasms / pathology* Prognosis Promoter Regions, Genetic / genetics |
| IF | 4.966 |
| 引用数 | 6 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RBE(RCB1292) SSP-25(RCB1293) YSCCC(RCB1549) PANC-1(RCB2095) PK-8(RCB2700) PK-59(RCB1901) KLM-1(RCB2138) MIA Paca2(RCB2094) |