論文 - 詳細
| RRC ID | 45538 |
|---|---|
| 著者 | Cheong MC, Artyukhin AB, You YJ, Avery L. |
| タイトル | An opioid-like system regulating feeding behavior in C. elegans. |
| ジャーナル | Elife |
| Abstract |
Neuropeptides are essential for the regulation of appetite. Here we show that neuropeptides could regulate feeding in mutants that lack neurotransmission from the motor neurons that stimulate feeding muscles. We identified nlp-24 by an RNAi screen of 115 neuropeptide genes, testing whether they affected growth. NLP-24 peptides have a conserved YGGXX sequence, similar to mammalian opioid neuropeptides. In addition, morphine and naloxone respectively stimulated and inhibited feeding in starved worms, but not in worms lacking NPR-17, which encodes a protein with sequence similarity to opioid receptors. Opioid agonists activated heterologously expressed NPR-17, as did at least one NLP-24 peptide. Worms lacking the ASI neurons, which express npr-17, did not response to naloxone. Thus, we suggest that Caenorhabditis elegans has an endogenous opioid system that acts through NPR-17, and that opioids regulate feeding via ASI neurons. Together, these results suggest C. elegans may be the first genetically tractable invertebrate opioid model. |
| 巻・号 | 4 |
| 公開日 | 2015-4-21 |
| DOI | 10.7554/eLife.06683 |
| PMID | 25898004 |
| PMC | PMC4427864 |
| MeSH | Amino Acid Sequence Animals Caenorhabditis elegans / drug effects Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Conserved Sequence Feeding Behavior / drug effects Feeding Behavior / physiology* Gene Expression Regulation Molecular Sequence Data Morphine / pharmacology Naloxone / pharmacology Neurons / cytology Neurons / drug effects Neurons / metabolism* Neuropeptides / genetics Neuropeptides / metabolism* Receptors, Opioid / deficiency Receptors, Opioid / genetics* Signal Transduction Starvation / metabolism |
| IF | 7.08 |
| 引用数 | 20 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 14 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3210 tm3225 tm3023 tm2105 |