論文 - 詳細
| RRC ID | 45539 |
|---|---|
| 著者 | Chien SC, Gurling M, Kim C, Craft T, Forrester W, Garriga G. |
| タイトル | Autonomous and nonautonomous regulation of Wnt-mediated neuronal polarity by the C. elegans Ror kinase CAM-1. |
| ジャーナル | Dev Biol |
| Abstract |
Wnts are a conserved family of secreted glycoproteins that regulate various developmental processes in metazoans. Three of the five Caenorhabditis elegans Wnts, CWN-1, CWN-2 and EGL-20, and the sole Wnt receptor of the Ror kinase family, CAM-1, are known to regulate the anterior polarization of the mechanosensory neuron ALM. Here we show that CAM-1 and the Frizzled receptor MOM-5 act in parallel pathways to control ALM polarity. We also show that CAM-1 has two functions in this process: an autonomous signaling function that promotes anterior polarization and a nonautonomous Wnt-antagonistic function that inhibits anterior polarization. These antagonistic activities can account for the weak ALM phenotypes displayed by cam-1 mutants. Our observations suggest that CAM-1 could function as a Wnt receptor in many developmental processes, but the analysis of cam-1 mutants may fail to reveal CAM-1's role as a receptor in these processes because of its Wnt-antagonistic activity. In this model, loss of CAM-1 results in increased levels of Wnts that act through other Wnt receptors, masking CAM-1's autonomous role as a Wnt receptor. |
| 巻・号 | 404(1) |
| ページ | 55-65 |
| 公開日 | 2015-8-1 |
| DOI | 10.1016/j.ydbio.2015.04.015 |
| PII | S0012-1606(15)00217-1 |
| PMID | 25917219 |
| PMC | PMC4556527 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / cytology* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / metabolism* Cell Polarity Membrane Proteins / metabolism* Neurons / cytology* Neurons / metabolism Receptor Tyrosine Kinase-like Orphan Receptors / metabolism* Wnt Signaling Pathway* |
| IF | 2.896 |
| 引用数 | 9 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 線虫 | tm1422 |