Reference - Detail
| RRC ID | 45605 |
|---|---|
| Author | Hao JC, Yu TW, Fujisawa K, Culotti JG, Gengyo-Ando K, Mitani S, Moulder G, Barstead R, Tessier-Lavigne M, Bargmann CI. |
| Title | C. elegans slit acts in midline, dorsal-ventral, and anterior-posterior guidance via the SAX-3/Robo receptor. |
| Journal | Neuron |
| Abstract |
Robo receptors interact with ligands of the Slit family. The nematode C. elegans has one Robo receptor (SAX-3) and one Slit protein (SLT-1), which direct ventral axon guidance and guidance at the midline. In larvae, slt-1 expression in dorsal muscles repels axons to promote ventral guidance. SLT-1 acts through the SAX-3 receptor, in parallel with the ventral attractant UNC-6 (Netrin). Removing both UNC-6 and SLT-1 eliminates all ventral guidance information for some axons, revealing an underlying longitudinal guidance pathway. In the embryo, slt-1 is expressed at high levels in anterior epidermis. Embryonic expression of SLT-1 provides anterior-posterior guidance information to migrating CAN neurons. Surprisingly, slt-1 mutants do not exhibit the nerve ring and epithelial defects of sax-3 mutants, suggesting that SAX-3 has both Slit-dependent and Slit-independent functions in development. |
| Volume | 32(1) |
| Pages | 25-38 |
| Published | 2001-10-11 |
| DOI | 10.1016/s0896-6273(01)00448-2 |
| PII | S0896-6273(01)00448-2 |
| PMID | 11604136 |
| MeSH | Animals Axons / physiology* Caenorhabditis elegans Caenorhabditis elegans Proteins* Cell Movement Gene Expression Regulation, Developmental Green Fluorescent Proteins Helminth Proteins / genetics Helminth Proteins / metabolism Indicators and Reagents / metabolism Luminescent Proteins / genetics Muscles / innervation Muscles / physiology Mutagenesis / physiology Nerve Tissue Proteins / chemistry Nerve Tissue Proteins / genetics* Nerve Tissue Proteins / metabolism* Netrins Neurons / physiology Neurons / ultrastructure Protein Structure, Tertiary Receptors, Immunologic / genetics* Receptors, Immunologic / metabolism* Roundabout Proteins |
| IF | 14.415 |
| Times Cited | 170 |
| WOS Category | NEUROSCIENCES |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 18 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm307 |