Reference - Detail
| RRC ID | 45640 |
|---|---|
| Author | Sammut M, Cook SJ, Nguyen KCQ, Felton T, Hall DH, Emmons SW, Poole RJ, Barrios A. |
| Title | Glia-derived neurons are required for sex-specific learning in C. elegans. |
| Journal | Nature |
| Abstract |
Sex differences in behaviour extend to cognitive-like processes such as learning, but the underlying dimorphisms in neural circuit development and organization that generate these behavioural differences are largely unknown. Here we define at the single-cell level-from development, through neural circuit connectivity, to function-the neural basis of a sex-specific learning in the nematode Caenorhabditis elegans. We show that sexual conditioning, a form of associative learning, requires a pair of male-specific interneurons whose progenitors are fully differentiated glia. These neurons are generated during sexual maturation and incorporated into pre-exisiting sex-shared circuits to couple chemotactic responses to reproductive priorities. Our findings reveal a general role for glia as neural progenitors across metazoan taxa and demonstrate that the addition of sex-specific neuron types to brain circuits during sexual maturation is an important mechanism for the generation of sexually dimorphic plasticity in learning. |
| Volume | 526(7573) |
| Pages | 385-390 |
| Published | 2015-10-15 |
| DOI | 10.1038/nature15700 |
| PMID | 26469050 |
| PMC | PMC4650210 |
| MeSH | Animals Brain / cytology Caenorhabditis elegans / cytology* Caenorhabditis elegans / physiology* Cell Division Cell Separation Cell Transdifferentiation Chemotaxis Conditioning, Classical / physiology Interneurons / classification Interneurons / cytology* Interneurons / physiology* Learning / physiology* Male Neural Pathways Neural Stem Cells / cytology Neurogenesis Neuroglia / cytology* Neuronal Plasticity Reproduction / physiology Sex Characteristics* Sexual Behavior, Animal / physiology Sexual Maturation Single-Cell Analysis |
| IF | 42.779 |
| Times Cited | 49 |
| WOS Category | NEUROSCIENCES |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 200 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1996 |