論文 - 詳細
| RRC ID | 45667 |
|---|---|
| 著者 | Zheng C, Diaz-Cuadros M, Chalfie M. |
| タイトル | Hox Genes Promote Neuronal Subtype Diversification through Posterior Induction in Caenorhabditis elegans. |
| ジャーナル | Neuron |
| Abstract |
Although Hox genes specify the differentiation of neuronal subtypes along the anterior-posterior axis, their mode of action is not entirely understood. Using two subtypes of the touch receptor neurons (TRNs) in C. elegans, we found that a "posterior induction" mechanism underlies the Hox control of terminal neuronal differentiation. The anterior subtype maintains a default TRN state, whereas the posterior subtype undergoes further morphological and transcriptional specification induced by the posterior Hox proteins, mainly EGL-5/Abd-B. Misexpression of the posterior Hox proteins transformed the anterior TRN subtype toward a posterior identity both morphologically and genetically. The specification of the posterior subtype requires EGL-5-induced repression of TALE cofactors, which antagonize EGL-5 functions, and the activation of rfip-1, a component of recycling endosomes, which mediates Hox activities by promoting subtype-specific neurite outgrowth. Finally, EGL-5 is required for subtype-specific circuit formation by acting in both the sensory neuron and downstream interneuron to promote functional connectivity. |
| 巻・号 | 88(3) |
| ページ | 514-27 |
| 公開日 | 2015-11-4 |
| DOI | 10.1016/j.neuron.2015.09.049 |
| PII | S0896-6273(15)00838-7 |
| PMID | 26539892 |
| PMC | PMC4635444 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / genetics* Caenorhabditis elegans / growth & development* Caenorhabditis elegans Proteins / genetics* Genes, Homeobox / genetics* Homeodomain Proteins / genetics* Interneurons / physiology* Mutation / genetics Sensory Receptor Cells / physiology* Transcription Factors / genetics* |
| IF | 14.415 |
| 引用数 | 14 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2341 tm2081 tm4746 |