RRC ID 45705
著者 Chen X, Chalfie M.
タイトル Modulation of C. elegans touch sensitivity is integrated at multiple levels.
ジャーナル J Neurosci
Abstract Sensory systems can adapt to different environmental signals. Here we identify four conditions that modulate anterior touch sensitivity in Caenorhabditis elegans after several hours and demonstrate that such sensory modulation is integrated at multiple levels to produce a single output. Prolonged vibration involving integrin signaling directly sensitizes the touch receptor neurons (TRNs). In contrast, hypoxia, the dauer state, and high salt reduce touch sensitivity by preventing the release of long-range neuroregulators, including two insulin-like proteins. Integration of these latter inputs occurs at upstream neurohormonal cells and at the insulin signaling cascade within the TRNs. These signals and those from integrin signaling converge to modulate touch sensitivity by regulating AKT kinases and DAF-16/FOXO. Thus, activation of either the integrin or insulin pathways can compensate for defects in the other pathway. This modulatory system integrates conflicting signals from different modalities, and adapts touch sensitivity to both mechanical and non-mechanical conditions.
巻・号 34(19)
ページ 6522-36
公開日 2014-5-7
DOI 10.1523/JNEUROSCI.0022-14.2014
PII 34/19/6522
PMID 24806678
PMC PMC4012311
MeSH Animals Behavior, Animal / physiology Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / physiology Calcium / physiology Forkhead Transcription Factors Hypoxia / physiopathology Integrins / physiology Lasers Mechanoreceptors / physiology Muscles / innervation Muscles / physiology Neuroimaging Oncogene Protein v-akt / physiology Physical Stimulation RNA Interference RNA, Messenger / biosynthesis RNA, Messenger / genetics Signal Transduction / physiology Stress, Physiological Touch Perception / physiology* Transcription Factors / physiology Vibration
IF 5.674
引用数 24
WOS 分野 NEUROSCIENCES
リソース情報
線虫 tm2988 tm3498 tm4990