論文 - 詳細
| RRC ID | 45705 |
|---|---|
| 著者 | Chen X, Chalfie M. |
| タイトル | Modulation of C. elegans touch sensitivity is integrated at multiple levels. |
| ジャーナル | J Neurosci |
| Abstract |
Sensory systems can adapt to different environmental signals. Here we identify four conditions that modulate anterior touch sensitivity in Caenorhabditis elegans after several hours and demonstrate that such sensory modulation is integrated at multiple levels to produce a single output. Prolonged vibration involving integrin signaling directly sensitizes the touch receptor neurons (TRNs). In contrast, hypoxia, the dauer state, and high salt reduce touch sensitivity by preventing the release of long-range neuroregulators, including two insulin-like proteins. Integration of these latter inputs occurs at upstream neurohormonal cells and at the insulin signaling cascade within the TRNs. These signals and those from integrin signaling converge to modulate touch sensitivity by regulating AKT kinases and DAF-16/FOXO. Thus, activation of either the integrin or insulin pathways can compensate for defects in the other pathway. This modulatory system integrates conflicting signals from different modalities, and adapts touch sensitivity to both mechanical and non-mechanical conditions. |
| 巻・号 | 34(19) |
| ページ | 6522-36 |
| 公開日 | 2014-5-7 |
| DOI | 10.1523/JNEUROSCI.0022-14.2014 |
| PII | 34/19/6522 |
| PMID | 24806678 |
| PMC | PMC4012311 |
| MeSH | Animals Behavior, Animal / physiology Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / physiology Calcium / physiology Forkhead Transcription Factors Hypoxia / physiopathology Integrins / physiology Lasers Mechanoreceptors / physiology Muscles / innervation Muscles / physiology Neuroimaging Oncogene Protein v-akt / physiology Physical Stimulation RNA Interference RNA, Messenger / biosynthesis RNA, Messenger / genetics Signal Transduction / physiology Stress, Physiological Touch Perception / physiology* Transcription Factors / physiology Vibration |
| IF | 5.674 |
| 引用数 | 24 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 線虫 | tm2988 tm3498 tm4990 |