Reference - Detail
| RRC ID | 45709 |
|---|---|
| Author | Chew YL, Fan X, Götz J, Nicholas HR. |
| Title | Regulation of age-related structural integrity in neurons by protein with tau-like repeats (PTL-1) is cell autonomous. |
| Journal | Sci Rep |
| Abstract |
PTL-1 is the sole homolog of the MAP2/MAP4/tau family in Caenorhabditis elegans. Accumulation of tau is a pathological hallmark of neurodegenerative diseases such as Alzheimer's disease. Therefore, reducing tau levels has been suggested as a therapeutic strategy. We previously showed that PTL-1 maintains age-related structural integrity in neurons, implying that excessive reduction in the levels of a tau-like protein is detrimental. Here, we demonstrate that the regulation of neuronal ageing by PTL-1 occurs via a cell-autonomous mechanism. We re-expressed PTL-1 in a null mutant background using a pan-neuronal promoter to show that PTL-1 functions in neurons to maintain structural integrity. We next expressed PTL-1 only in touch neurons and showed rescue of the neuronal ageing phenotype of ptl-1 mutant animals in these neurons but not in another neuronal subset, the ventral nerve cord GABAergic neurons. Knockdown of PTL-1 in touch neurons also resulted in premature neuronal ageing in these neurons but not in GABAergic neurons. Additionally, expression of PTL-1 in touch neurons alone was unable to rescue the shortened lifespan observed in ptl-1 mutants, but pan-neuronal re-expression restored wild-type longevity, indicating that, at least for a specific group of mechanosensory neurons, premature neuronal ageing and organismal ageing can be decoupled. |
| Volume | 4 |
| Pages | 5185 |
| Published | 2014-6-5 |
| DOI | 10.1038/srep05185 |
| PII | srep05185 |
| PMID | 24898126 |
| PMC | PMC4046136 |
| MeSH | Animals Animals, Genetically Modified / genetics Animals, Genetically Modified / metabolism* Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / antagonists & inhibitors Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Fluorescent Antibody Technique Image Processing, Computer-Assisted Longevity / physiology* Microtubule-Associated Proteins / antagonists & inhibitors Microtubule-Associated Proteins / genetics Microtubule-Associated Proteins / metabolism* Neurons / cytology* Neurons / metabolism* RNA Interference |
| IF | 3.998 |
| Times Cited | 10 |
| WOS Category | NEUROSCIENCES |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm543 |