論文 - 詳細
| RRC ID | 45730 |
|---|---|
| 著者 | Gao J, Kim HM, Elia AE, Elledge SJ, Colaiácovo MP. |
| タイトル | NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis. |
| ジャーナル | PLoS Genet |
| Abstract |
The formation of DNA double-strand breaks (DSBs) must take place during meiosis to ensure the formation of crossovers, which are required for accurate chromosome segregation, therefore avoiding aneuploidy. However, DSB formation must be tightly regulated to maintain genomic integrity. How this regulation operates in the context of different chromatin architectures and accessibility, and how it is linked to metabolic pathways, is not understood. We show here that global histone acetylation levels undergo changes throughout meiotic progression. Moreover, perturbations to global histone acetylation levels are accompanied by changes in the frequency of DSB formation in C. elegans. We provide evidence that the regulation of histone acetylation requires CRA-1, a NatB domain-containing protein homologous to human NAA25, which controls the levels of acetyl-Coenzyme A (acetyl-CoA) by antagonizing ACER-1, a previously unknown and conserved acetyl-CoA hydrolase. CRA-1 is in turn negatively regulated by XND-1, an AT-hook containing protein. We propose that this newly defined protein network links acetyl-CoA metabolism to meiotic DSB formation via modulation of global histone acetylation. |
| 巻・号 | 11(3) |
| ページ | e1005029 |
| 公開日 | 2015-3-1 |
| DOI | 10.1371/journal.pgen.1005029 |
| PII | PGENETICS-D-14-03109 |
| PMID | 25768301 |
| PMC | PMC4359108 |
| MeSH | Acetyl Coenzyme A / metabolism* Acetyl-CoA Hydrolase / metabolism* Acetylation Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism* DNA Breaks, Double-Stranded Histones / metabolism Recombination, Genetic* X Chromosome / metabolism |
| IF | 5.175 |
| 引用数 | 8 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1086 tm2144 |