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  • Search Condition : Filter (MeSH = DNA Breaks, Double-Stranded)
Species Resource Title
Algae NIES-2145 Double-strand break-free and transgene-free genome editing in the microalga Nannochloropsis oceanica using removable vectors containing the CRISPR base editing system.
C.elegans tm1524 , em2134 Analysis of rad-51 separation of function allele suggests divergence of the synthesis-dependent strand annealing and double Holliday junction pathways prior to RAD-51 filament disassembly.
C.elegans tm2842 , tm2644 Bloom helicase contributes to successful crossover formation with both catalytic and structural roles in Caenorhabditis elegans meiosis.
C.elegans tm1937 , tm2026 , tm1145 Damage-induced phosphorylation of BRC-1/BRD-1 in meiosis preserves germline integrity.
Drosophila DGRC#203684 Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51.
Aged mice Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma.
Human and Animal Cells NB1RGB(RCB0222) Live-cell imaging of DNA damage and cell cycle progression uncovers distinct responses during neural differentiation of hiPSCs.
C.elegans tm1458 The conserved ATPase PCH-2 controls the number and distribution of crossovers by antagonizing their formation in Caenorhabditis elegans.
C.elegans tm1458 , tm3655 A chromosome-coupled ubiquitin-proteasome pathway is required for meiotic surveillance.
Drosophila DGRC#107748 Repeat mediated excision of gene drive elements for restoring wild-type populations.
DNA material CSIV-TRE-RfA-UbC-KT (RDB12878) , CS-RfA-ETBsd (RDB07917) Ribosomal S6 kinase (RSK) plays a critical role in DNA damage response via the phosphorylation of histone lysine demethylase KDM4B.
Drosophila DGRC#101260 RNA polymerase II-mediated rDNA transcription mediates rDNA copy number expansion in Drosophila.
Human and Animal Cells HUDEP-2(RCB4557) Generation of scalable cancer models by combining AAV-intron-trap, CRISPR/Cas9, and inducible Cre-recombinase.
C.elegans tm1524 , tm2026 , tm1086 PARG and BRCA1-BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis.
C.elegans rad-54 Aging and sperm signals alter DNA break formation and repair in the C. elegans germline.
C.elegans tm5034 Chromatin landscape, DSB levels, and cKU-70/80 contribute to patterning of meiotic DSB processing along chromosomes in C. elegans.
C.elegans Continuous double-strand break induction and their differential processing sustain chiasma formation during Caenorhabditis elegans meiosis.
C.elegans tm5034 , tm853 , tm1598 , tm3655 Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity.
C.elegans tm1524 , tm3298 Caenorhabditis elegans RMI2 functional homolog-2 (RMIF-2) and RMI1 (RMH-1) have both overlapping and distinct meiotic functions within the BTR complex.
Human and Animal Cells HeLa.S3(RCB1525) Optimal timing of a γH2AX analysis to predict cellular lethal damage in cultured tumor cell lines after exposure to diagnostic and therapeutic radiation doses.