論文 - 詳細
| RRC ID | 45752 |
|---|---|
| 著者 | Hung WL, Wang Y, Chitturi J, Zhen M. |
| タイトル | A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication. |
| ジャーナル | Development |
| Abstract |
Adverse environmental conditions trigger C. elegans larvae to activate an alternative developmental program, termed dauer diapause, which renders them stress resistant. High-level insulin signaling prevents constitutive dauer formation. However, it is not fully understood how animals assess conditions to choose the optimal developmental program. Here, we show that insulin-like peptide (ILP)-mediated neuron-intestine communication plays a role in this developmental decision. Consistent with, and extending, previous findings, we show that the simultaneous removal of INS-4, INS-6 and DAF-28 leads to fully penetrant constitutive dauer formation, whereas the removal of INS-1 and INS-18 significantly inhibits constitutive dauer formation. These ligands are processed by the proprotein convertases PC1/KPC-1 and/or PC2/EGL-3. The agonistic and antagonistic ligands are expressed by, and function in, neurons to prevent or promote dauer formation. By contrast, the insulin receptor DAF-2 and its effector, the FOXO transcription factor DAF-16, function solely in the intestine to regulate the decision to enter diapause. These results suggest that the nervous system normally establishes an agonistic ILP-dominant paradigm to inhibit intestinal DAF-16 activation and allow reproductive development. Under adverse conditions, a switch in the agonistic-antagonistic ILP balance activates intestinal DAF-16, which commits animals to diapause. |
| 巻・号 | 141(8) |
| ページ | 1767-79 |
| 公開日 | 2014-4-1 |
| DOI | 10.1242/dev.103846 |
| PII | dev.103846 |
| PMID | 24671950 |
| PMC | PMC3978837 |
| MeSH | Animals Caenorhabditis elegans / growth & development* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism Cell Communication* Green Fluorescent Proteins / metabolism Insulin / metabolism* Intestinal Mucosa / metabolism Intestines / cytology* Larva / metabolism Models, Biological Motor Neurons / cytology Motor Neurons / metabolism Neurons / cytology* Neurons / metabolism Sensory Receptor Cells / cytology Sensory Receptor Cells / metabolism Signal Transduction* |
| IF | 5.611 |
| 引用数 | 43 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2308 tm1888 tm4467 tm3608 tm3620 tm2560 tm2416 tm2001 tm4144 |