論文 - 詳細
| RRC ID | 45771 |
|---|---|
| 著者 | Kim Y, Rosenberg SC, Kugel CL, Kostow N, Rog O, Davydov V, Su TY, Dernburg AF, Corbett KD. |
| タイトル | The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins. |
| ジャーナル | Dev Cell |
| Abstract |
Proteins of the HORMA domain family play central, but poorly understood, roles in chromosome organization and dynamics during meiosis. In Caenorhabditis elegans, four such proteins (HIM-3, HTP-1, HTP-2, and HTP-3) have distinct but overlapping functions. Through combined biochemical, structural, and in vivo analysis, we find that these proteins form hierarchical complexes through binding of their HORMA domains to cognate peptides within their partners' C-terminal tails, analogous to the "safety belt" binding mechanism of Mad2. These interactions are critical for recruitment of HIM-3, HTP-1, and HTP-2 to chromosome axes. HTP-3, in addition to recruiting the other HORMA domain proteins to the axis, plays an independent role in sister chromatid cohesion and double-strand break formation. Finally, we find that mammalian HORMAD1 binds a motif found both at its own C terminus and at that of HORMAD2, indicating that this mode of intermolecular association is a conserved feature of meiotic chromosome structure in eukaryotes. |
| 巻・号 | 31(4) |
| ページ | 487-502 |
| 公開日 | 2014-11-24 |
| DOI | 10.1016/j.devcel.2014.09.013 |
| PII | S1534-5807(14)00619-4 |
| PMID | 25446517 |
| PMC | PMC4254552 |
| MeSH | Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism* Cell Cycle Proteins / metabolism* Chromosome Pairing / genetics* Chromosome Segregation / physiology Chromosomes / metabolism* Meiosis / physiology* Mutation / genetics Synaptonemal Complex / metabolism* |
| IF | 10.092 |
| 引用数 | 40 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3655 |